Results 111 to 120 of about 3,406,662 (333)

Active ageing: controlling the (ageing) bodies

, 2012
This study focuses on the concept of active ageing in the “Active Ageing: A Policy Framework” by World Health Organization. The purpose is to understand the meaning and the origins of the concept with the help of Foucauldian perspective.
Kiuru, Hilla
core  

Frailty, a multisystem ageing syndrome

, 2020
The management of frail older people is a key component of aged care. There has been a plethora of tools developed for the diagnosis and screening of frailty. Some of these tools are entering routine clinical practice at a time when the higher healthcare
Thillainadesan, Janani, Le Couteur, David G., Scott, Ian A.   +2 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Discovering the direct relations between nutrients and epigenetic ageing

The Journal of Nutrition, Health and Aging
Background: Along with the ageing of society, the absolute prevalence of age-related diseases is expected to rise, leading to a substantial burden on healthcare systems and society. Thus, there is an urgent need to promote healthy ageing.
Pol Grootswagers, Daimy Bach, Ynte Biemans, Pariya Behrouzi, Steve Horvath, Charlotte S. Kramer, Simin Liu, JoAnn E. Manson, Aladdin H. Shadyab, James D. Stewart, Eric Whitsel, Bo Yang, Lisette de Groot   +12 more
doaj   +1 more source

Genomic signatures of adaptation to wine biological ageing conditions in biofilm‐forming flor yeasts

Molecular Ecology, 2017
The molecular and evolutionary processes underlying fungal domestication remain largely unknown despite the importance of fungi to bioindustry and for comparative adaptation genomics in eukaryotes. Wine fermentation and biological ageing are performed by
Anna-Lisa Coi, F. Bigey, S. Mallet, S. Marsit, G. Zara, P. Gladieux, Virginie Galeote, M. Budroni, S. Dequin, J. Legras   +9 more
semanticscholar   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Oxidative stress and epigenetic regulation in ageing and age-related diseases

, 2013
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available ...
Francesco Spallotta, Spallotta, Francesco, Gaetano, Carlo, Sergio Valente, Chiara Cencioni, Antonello Mai, Cencioni, Chiara, Valente, Sergio, Carlo Gaetano, Mai, Antonello, Martelli, Fabio, Zeiher, Andreas M., Fabio Martelli, Andreas Zeiher   +13 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Secrets from immortal worms: What can we learn about biological ageing from the planarian model system?

Seminars in Cell and Developmental Biology, 2017
Understanding how some animals are immortal and avoid the ageing process is important. We currently know very little about how they achieve this. Research with genetic model systems has revealed the existence of conserved genetic pathways and molecular ...
Sounak Sahu, Anish Dattani, A. Aboobaker
semanticscholar   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source