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The human gut microbiome across the life course
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Embodying 'active' ageing: bodies, emotions and risk in later life [PDF]
The promotion of 'active' ageing in later life has been a key development in recent health policy. These changes not only challenge the prevalent view of old age as an inevitable process of biological decline but signify the tendency of lay and expert ...
Martin, Wendy
core
Ageing between Gerontology and Biomedicine. [PDF]
Over the past two decades, public interest in the basic biological processes underlying the phenomenon of ageing has grown considerably. New developments in biotechnology and health maintenance programmes appear to be forging new relationships between ...
Palladino, Paolo, Moreira, Tiago
core
2. Physical and biological aspects of ageing
‘Physical and biological aspects of ageing’ considers influences on longevity and the physical disorders commonly experienced at the end of life. It describes primary and secondary ageing and different biological theories of ageing—error and programme ...
Nancy A. Pachana
core +1 more source
Telomere length- A biological marker of ageing
Telomere length is an indicator of biological age, influenced mainly by oxidative stress and inflammatory conditions. Telomere length shortens with advancing age, however in certain situations this shortening expedites with early senile changes while in ...
Binafsha Manzoor Syed
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
The analysis of network topology and dynamics is increasingly used for the description of the structure, function and evolution of complex systems.
Huba J. M. Kiss +6 more
core
POPULATION STRUCTURE IN THE PENNA MODEL
Numerical simulations of growing population, based on the Penna model, are presented. We consider biological ageing as a result of the accumulation of mutations in the genotype. We present an example of simulated population structure and compare it with
MIKOŁAJ SITARZ
doaj
Social position is known to play a role in the quality of ageing, notably through the stimulation/dysregulation of key physiological systems in response to external stresses.
M. Karimi +8 more
semanticscholar +1 more source
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source

