Results 91 to 100 of about 3,406,662 (333)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Analytical and sensory characterisation of Palo Cortado in comparison with Amontillado and Oloroso Sherry wines

OENO One
This research focuses on the analytical and sensory characterisation of Palo Cortado Sherry wines, using Amontillado and Oloroso as reference styles within the spectrum of biological-to-oxidative ageing spectrum of Sherry wines from the Jerez region ...
Alondra Brito Rendon, Manuel Malfeito-Ferreira, Cristina Mariana Lasanta Melero, Antonio Dionisio Morata Barrado   +3 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Comparative Dynamics of Individual Ageing among the Investigative Type of Professionals Living in Russia and Russian Migrants to the EU Countries

European Journal of Investigation in Health, Psychology and Education, 2020
The goal of this study was to uncover the influence of professional activity, migration, and gender on dynamics of subjective age and ageing biomarkers.
Tatiana N. Berezina, Natalia N. Rybtsova, Stanislav A. Rybtsov   +2 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

From Phenotypes to Spectrum: Rethinking RRMS, SPMS and PPMS in the Era of PIRA—A Framework Integrating PIRA, Smouldering-Associated Worsening, and Neurologic Reserve to Facilitate Earlier Recognition of Progression

Neurology International
The conventional classification of multiple sclerosis (MS) into relapsing–remitting, secondary progressive, and primary progressive phenotypes has long guided diagnosis, prognosis, and therapeutic decision-making. However, accumulating evidence indicates
Georgi V. Vasilev, Sonya Ivanova, Ivan Milanov   +2 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Understanding ageing : biological and social perspectives

, 2014
In this chapter, we discuss how social and biological studies of ageing can converge to provide a meaningful framework for progress in both understanding ageing and dealing with it in a positive manner.
David Steinsaltz, Peter V.E. McClintock, Latimer, Joanne, Alan Bernjak, Latimer, Joanna E., Davis, Terence, Mason, Penelope A., Joanna E. Latimer, Stefanovska, Aneta, Anna C. Phillips, Jane Upton, Bagley, Mark, Bernjak, Alan, Upton, Jane, McClinktock, Peter, Bagley, Mark C., Whittaker, Anna; id_orcid, Lynne S. Cox, Cox, Lynne S., Terence Davis, Mark C. Bagley, Phillips, Anna C., Steinsaltz, David, Penelope A. Mason, Upton, Mary Jane, Aneta Stefanovska, McClintock, Peter V. E., Mason, Penelop   +27 more
core   +1 more source

Slug, a Cancer‐Related Transcription Factor, is Involved in Vascular Smooth Muscle Cell Transdifferentiation Induced by Platelet‐Derived Growth Factor‐BB During Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Heart attacks and stroke often result from occlusive thrombi following the rupture of vulnerable atherosclerotic plaques. Vascular smooth muscle cells (VSMCs) play a pivotal role in plaque vulnerability because of their switch towards a ...
Nahéma Ledard, Alexandrine Liboz, Bertrand Blondeau, Mégane Babiak, Célia Moulin, Benjamin Vallin, Isabelle Guillas, Véronique Mateo, Claire Jumeau, Karl Blirando, Olivier Meilhac, Isabelle Limon, Martine Glorian   +12 more
doaj   +1 more source

Time and Biological Age

Arbor: Ciencia, Pensamiento y Cultura, 2013
189
Vargas, Esteban, Espinoza, Ricardo
openaire   +3 more sources