Results 81 to 90 of about 3,406,662 (333)

A pro-oxidant combination of resveratrol and copper down-regulates multiple biological hallmarks of ageing and neurodegeneration in mice

Scientific Reports, 2022
Billions of cells die in the body every day, and cell-free chromatin particles (cfChPs) which are released from them enter into the extracellular compartments of the body, including into the circulation.
Kavita Pal, G. V. Raghuram, Jenevieve Dsouza, Sushma Shinde, Vishal Jadhav, A. Shaikh, Bhagyeshri Rane, Harshali Tandel, Dipali Kondhalkar, S. Chaudhary, I. Mittra   +10 more
semanticscholar   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Hemostasis and ageing [PDF]

, 2008
On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related Diseases was held in Palermo, Italy. The lecture of D. Mari on Hemostasis and ageing is summarized herein.
Mari Daniela, G. Vitale, LIO, Domenico, Giulia Ogliari, Bollini Elisa, Castaldi Davide, G. Ogliari, Giovanni Vitale, E.M. Bollini, Elisa M Bollini, Vitale Giovanni, Lio Domenico, Vitale G, D. Mari, Ogliari Giulia, Castaldi D, Daniela Mari, Domenico Lio, Bollini EM, Davide Castaldi, Ogliari G, D. Castaldi, D. Lio, Mari D   +23 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Profiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults

, 2012
Advancing age is associated with cardiovascular disease, diabetes mellitus and cancer, and shows significant inter-individual variability. To identify ageing-related biomarkers we performed a proteomic analysis on 1890 Chinese Han individuals, 1136 males
Manshu Song (153063), Xinwei Yu (153054), Feifei Zhao, Li, Y., Manshu Song, Jingjing Wu (153040), Alan H Bittles, Jiapeng Lu (153024), Zhang, Y., Jiapeng Lu, Wei Wang, Wang, Youxin, Yu, Xinwei, Meng, S., Wu, Jingjing, Song, Manshu, Huang, Y., Qingwei Ma (153058), Chang, Naibai, Shijiao Meng, Meng, Shijiao, Shijiao Meng (153050), Wang, Y., Naibai Chang, Xinwei Yu, Zhang, Youjun, Wang, Wei, Huang, Yuqing, Naibai Chang (153067), Yuqing Huang, Qingwei Ma, Yujun Zhang, Youxin Wang (153032), Yuqing Huang (153028), Alan H. Bittles (153071), Li, Yan, Yan Li (23143), Wei Wang (17594), Zhao, Feifei, Chang, N., Bittles, A.H., Yan Li, Song, M., Yujun Zhang (118792), Yu, X., Feifei Zhao (153044), Ma, Qingwei, Wu, J., Zhao, F., Lu, Jiapeng, Bittles, Alan H., Lu, J., Jingjing Wu, Ma, Q., Youxin Wang, Wang, W.   +55 more
core   +1 more source

Telomere length and COVID-19 disease severity: insights from hospitalized patients

Frontiers in Aging
IntroductionTelomere length is associated with various disease and immune function and may therefore impact COVID-19 disease severity. We studied the associations between telomere length as a geroprotective susceptibility marker and clinical outcomes in ...
Stijn Vos, Dries S. Martens, Elien De Waele, Geert Dewyspelaere, Geert Mistiaen, Pieter Goeminne, Tim S. Nawrot, Tim S. Nawrot   +7 more
doaj   +1 more source

Apoptosis and premature aging in patients with metabolic syndrome [PDF]

Саратовский научно-медицинский журнал, 2012
The Research Objective: Correlation of apoptosis and senilism in patients with metabolic syndrome has been studied. Materials. Apoptosis inductor protein p53 concentration, insulin level in blood serum, biological age, ageing rate coefficient of 270 ...
Panova T.N., Chernysheva E.N.
doaj  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

Redox Biology, 2015
IL-1β production is critically regulated by cytosolic molecular complexes, termed inflammasomes. Different inflammasome complexes have been described to date.
Amna Abderrazak, Tatiana Syrovets, Dominique Couchie, Khadija El Hadri, Bertrand Friguet, Thomas Simmet, Mustapha Rouis   +6 more
doaj   +1 more source

Making Biological Ageing Clocks Personal

medRxiv
Age is the most important risk factor for the majority of human diseases. Addressing the impact of age-related diseases has become a priority in healthcare practice, leading to the exploration of innovative approaches, including the development of ...
M. Pusparum, O. Thas, S. Beck, G. Ertaylan, S. Ecker   +4 more
semanticscholar   +1 more source