Results 61 to 70 of about 3,406,662 (333)

Cyto- and bio-compatibility assessment of plasma-treated polyvinylidene fluoride scaffolds for cardiac tissue engineering

Frontiers in Bioengineering and Biotechnology, 2022
As part of applications dealing with cardiovascular tissue engineering, drop-cast polyvinylidene fluoride (PVDF) scaffolds have been treated by cold plasma to enhance their adherence to cardiac cells.
Maria Kitsara, Gaëlle Revet, Jean-Sébastien Vartanian-Grimaldi, Alexandre Simon, Mathilde Minguy, Antoine Miche, Vincent Humblot, Vincent Humblot, Thierry Dufour, Onnik Agbulut   +9 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

The Oxidized Protein Repair Enzymes Methionine Sulfoxide Reductases and Their Roles in Protecting against Oxidative Stress, in Ageing and in Regulating Protein Function

Antioxidants, 2018
Cysteine and methionine residues are the amino acids most sensitive to oxidation by reactive oxygen species. However, in contrast to other amino acids, certain cysteine and methionine oxidation products can be reduced within proteins by dedicated ...
Sofia Lourenço dos Santos, Isabelle Petropoulos, Bertrand Friguet   +2 more
doaj   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

ON PENNA MODEL OF POPULATION EVOLUTION

TASK Quarterly, 2000
Computer studies of population evolution are presented. Numerical calculations are based on the Penna model. This model accounts for mutation load of individuals resulting in non-trivial age (a) dependence of the mortality rate q(a) which may be ...
MARIA MAGDOŃ-MAKSYMOWICZ
doaj  

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

Genome Medicine, 2019
DNA methylation changes with age. Chronological age predictors built from DNA methylation are termed ‘epigenetic clocks’. The deviation of predicted age from the actual age (‘age acceleration residual’, AAR) has been reported to be associated with death.
Qian Zhang, C. Vallerga, R. Walker, Tian Lin, A. Henders, G. Montgomery, Ji He, Dongsheng Fan, Javed Fowdar, M. Kennedy, Toni L. Pitcher, J. Pearson, G. Halliday, J. Kwok, I. Hickie, S. Lewis, T. Anderson, P. Silburn, G. Mellick, S. Harris, P. Redmond, A. Murray, D. Porteous, C. Haley, K. Evans, A. McIntosh, Jian Yang, J. Gratten, R. Marioni, N. Wray, I. Deary, A. McRae, P. Visscher   +32 more
semanticscholar   +1 more source

DNA methylation-based measures of accelerated biological ageing and the risk of dementia in the oldest-old: a study of the Lothian Birth Cohort 1921

BMC Psychiatry, 2020
Background Previous studies have demonstrated an association between DNA methylation-based measures of accelerated ageing and age-related health outcomes and mortality.
Ruth A. Sibbett, D. Altschul, R. Marioni, I. Deary, J. Starr, Tom C. Russ   +5 more
semanticscholar   +1 more source

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source

Association of facial ageing with DNA methylation and epigenetic age predictions

Clinical Epigenetics, 2018
Evaluation of biological age, as opposed to chronological age, is of high relevance for interventions to increase healthy ageing. Highly reproducible age-associated DNA methylation (DNAm) changes can be integrated into algorithms for epigenetic age ...
Riccardo E. Marioni, Daniel W. Belsky, Ian J. Deary, Wolfgang Wagner   +3 more
doaj   +1 more source

The mTOR–lysosome axis at the centre of ageing

FEBS Open Bio, 2022
Age‐related diseases represent some of the largest unmet clinical needs of our time. While treatment of specific disease‐related signs has had some success (for example, the effect of statin drugs on slowing progression of atherosclerosis), slowing ...
Julian M. Carosi, Célia Fourrier, Julien Bensalem, Timothy J. Sargeant   +3 more
doaj   +1 more source