Results 141 to 150 of about 2,895,252 (212)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Other title: Aging and Disabilities Resource Center Overview

open access: yes, 2017
April 19, 2017. Date and committee name taken from Kansas Department for Aging and Disability Services website.; Information provided to the Kansas Legislature, Robert G. Bethell Joint Committee, by the Kansas Department for Aging and Disability Services.
Kansas. Department for Aging and Disability Services.
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Double Jeopardy Project summary of focus group results.

open access: yes, 2002
Title from title screen.; Harvested from the web on 9/4/02Summarizes the results of focus groups conducted to support the "Double Jeopardy" project: supporting families in planning for a secure future for their adult children with developmental ...
Ohio.Dept. of Aging.
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Other title: Kansas Department for Aging and Disability Services Overview; Other title: Overview

open access: yes, 2018
application/pdf; "1/11/2018."; Committee name taken from Kansas Department for Aging and Disability Services website.; Presentation before the Kansas Legislature, House Children and Seniors Committee, by the Kansas Department for Aging and Disability ...
Kansas. Department for Aging and Disability Services.
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Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

PASSPORT client satisfaction survey results for ...

open access: yes, 2004
Annual; Description based on: FY 2003 (Mar. 2004); title from cover of PDF document (viewed Aug. 11, 2005).; Also includes comparison to previous FY results.; Harvested from the web on 8/11/05Since 1996, the Ohio Dept.
Ohio. Dept. of Aging.
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