Results 131 to 140 of about 911,648 (354)

Epigenetic and microbiome responses to greens supplementation in obese older adults: results from a randomized crossover-controlled trial

Frontiers in Nutrition
Aging is influenced by genetic, environmental, and lifestyle factors. Preliminary studies suggest that fruit and vegetable-based dietary supplements may reduce inflammation and oxidative stress, key factors in aging.
Laura A. Robinson, Laura A. Robinson, Aidan M. Cavanah, Aidan M. Cavanah, Sarah Lennon, Sarah Lennon, Madison L. Mattingly, William Van Der Pol, Kevin W. Huggins, Michael W. Greene, Michael D. Roberts, Andrew D. Frugé, Andrew D. Frugé   +12 more
doaj   +1 more source

Social mobility and biological aging among older adults in the United States [PDF]

, 2022
Gloria Huei-Jong Graf, Yalu Zhang, Benjamin W. Domingue, Kathleen Mullan Harris, Meeraj Kothari, Dayoon Kwon, Peter Muennig, Daniel W. Belsky   +7 more
openalex   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Cellular Senescence as a Targetable Risk Factor for Cardiovascular Diseases

JACC: Basic to Translational Science
Summary: The prevalence of cardiovascular diseases markedly rises with age. Cellular senescence, a hallmark of aging, is characterized by irreversible cell cycle arrest and the manifestation of a senescence-associated secretory phenotype, which has ...
Manish Kumar, MD, Pengyi Yan, PhD, George A. Kuchel, MD, Ming Xu, PhD   +3 more
doaj   +1 more source

The Genetic Architecture of Biological Age in Nine Human Organ Systems [PDF]

, 2023
Junhao Wen, Ye Tian, Ioanna Skampardoni, Zhijian Yang, Yuhan Cui, Filippos Anagnostakis, Elizabeth Mamourian, Bingxin Zhao, Arthur W. Toga, Andrew Zaleskey, Christos Davatzikos   +10 more
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Associations of Epigenetic Age Acceleration With CVD Risks Across the Lifespan

JACC: Basic to Translational Science
Summary: Although epigenetic age acceleration (EAA) might serve as a molecular signature of childhood cardiovascular disease (CVD) risk factors and further promote midlife subclinical CVD, few studies have comprehensively examined these life course ...
Xiao Sun, PhD, Wei Chen, MD, PhD, Alexander C. Razavi, MD, PhD, MPH, Mengyao Shi, PhD, MPH, Yang Pan, PhD, Changwei Li, MD, PhD, Maria Argos, PhD, Brian T. Layden, MD, Martha L. Daviglus, MD, PhD, Jiang He, MD, PhD, Owen T. Carmichael, PhD, Lydia A. Bazzano, MD, PhD, Tanika N. Kelly, PhD, MPH   +12 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION The geroscience hypothesis proposes systemic biological aging is a root cause of cognitive decline. METHODS We analyzed Framingham Heart Study Offspring Cohort data (n = 2296; 46% male; baseline age M = 62, SD = 9, range = 25–101 y).
Micah J. Savin, Haoyang Wang, Heming Pei, Allison E. Aiello, Stephanie Assuras, Avshalom Caspi, Terrie E. Moffitt, Peter A. Muenning, Calen P. Ryan, Baoyi Shi, Yaakov Stern, Karen Sugden, Linda Valeri, Daniel W. Belsky   +13 more
doaj   +1 more source

Long Telomeric Repeat-Containing RNA (TERRA): Biological Functions and Challenges in Vascular Aging and Disease [PDF]

, 2023
Paola Canale, Jonica Campolo, Andrea Borghini, Maria Grazia Andreassi   +3 more
openalex   +1 more source