Results 1 to 10 of about 21,361 (121)

Slowing down decay: biological clocks in personalized medicine [PDF]

Frontiers in Sociology, 2023
This article discusses so-called biological clocks. These technologies, based on aging biomarkers, trace and measure molecular changes in order to monitor individuals' “true” biological age against their chronological age. Drawing on the concept of decay,
Clémence Pinel, Sara Green, Mette N. Svendsen   +2 more
doaj   +2 more sources

An integrative study of five biological clocks in somatic and mental health [PDF]

eLife, 2021
Biological clocks have been developed at different molecular levels and were found to be more advanced in the presence of somatic illness and mental disorders. However, it is unclear whether different biological clocks reflect similar aging processes and
Rick Jansen, Laura KM Han, Josine E Verhoeven, Karolina A Aberg, Edwin CGJ van den Oord, Yuri Milaneschi, Brenda WJH Penninx   +6 more
doaj   +2 more sources

An oligogenic architecture underlying ecological and reproductive divergence in sympatric populations

eLife, 2023
The evolutionary trajectories and genetic architectures underlying ecological divergence with gene flow are poorly understood. Sympatric timing types of the intertidal insect Clunio marinus (Diptera) from Roscoff (France) differ in lunar reproductive ...
Dušica Briševac, Carolina M Peralta, Tobias S Kaiser   +2 more
doaj   +1 more source

Circadian Clock Control of Translation Initiation Factor eIF2α Activity Requires eIF2γ-Dependent Recruitment of Rhythmic PPP-1 Phosphatase in Neurospora crassa

mBio, 2021
Circadian clock control of mRNA translation contributes to the daily cycling of a significant proportion of the cellular protein synthesis, but how this is accomplished is not understood.
Zhaolan Ding, Teresa M. Lamb, Ahmad Boukhris, Rachel Porter, Deborah Bell-Pedersen   +4 more
doaj   +1 more source

Crosstalk between vrille transcripts, proteins, and regulatory elements controlling circadian rhythms and development in Drosophila

iScience, 2021
Summary: The vrille (vri) gene encodes a transcriptional repressor required for Drosophila development as well as circadian behavior in adults. Alternate first exons produce vri transcripts predicted to produce a short VRI isoform during development and ...
Kushan L. Gunawardhana, Gustavo B.S. Rivas, Courtney Caster, Paul E. Hardin   +3 more
doaj   +1 more source

Cryptochrome 1 mediates light-dependent inclination magnetosensing in monarch butterflies

Nature Communications, 2021
Exactly how some animals use magnetic fields to navigate is a longstanding puzzle. A study using a new behavioural assay and transgenic butterflies finds the cryptochrome gene necessary for inclination-based magnetic sensing, and shows that both antennae
Guijun Wan, Ashley N. Hayden, Samantha E. Iiams, Christine Merlin   +3 more
doaj   +1 more source

Assessing the Causal Association between Biological Aging Biomarkers and the Development of Cerebral Small Vessel Disease: A Mendelian Randomization Study

Biology, 2023
Biological aging biomarkers, such as leukocyte telomere length (LTL) and epigenetic clocks, have been associated with the risk of cerebral small vessel disease (CSVD) in several observational studies.
Biying Lin, Yuzhu Mu, Zhongxiang Ding
doaj   +1 more source

Evaluation of pediatric epigenetic clocks across multiple tissues

Clinical Epigenetics, 2023
Background Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination.
Fang Fang, Linran Zhou, Wei Perng, Carmen J. Marsit, Anna K. Knight, Andres Cardenas, Max T. Aung, Marie-France Hivert, Izzuddin M. Aris, Jaclyn M. Goodrich, Alicia K. Smith, Abigail Gaylord, Rebecca C. Fry, Emily Oken, George O’Connor, Douglas M. Ruden, Leonardo Trasande, Julie B. Herbstman, Carlos A. Camargo, Nicole R. Bush, Anne L. Dunlop, Dana M. Dabelea, Margaret R. Karagas, Carrie V. Breton, Carole Ober, Todd M. Everson, Grier P. Page, Christine Ladd-Acosta, on behalf of program collaborators for Environmental influences on Child Health Outcomes   +28 more
doaj   +1 more source

Macrophage Meets the Circadian Clock: Implication of the Circadian Clock in the Role of Macrophages in Acute Lower Respiratory Tract Infection

Frontiers in Cellular and Infection Microbiology, 2022
The circadian rhythm is a biological system that creates daily variations of physiology and behavior with a 24-h cycle, which is precisely controlled by the molecular circadian clock.
Ken Shirato, Shogo Sato
doaj   +1 more source

Towards Cancer Theory – Circadian and 11-Day Biological Clocks [PDF]

Middle East Journal of Cancer, 2021
Background: In the current study, we used the information-hierarchical system approach to examine human metabolism. Metabolism hierarchical structure, beginning from enzyme level, is controlled by the established information principle and divine section ...
Yuri Kirsta, Dmitry Kirsta
doaj   +1 more source