Results 241 to 250 of about 67,445 (310)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Uncertainty Quantification in Epigenetic Clocks via Conformalized Quantile Regression. [PDF]

Genet Epidemiol
Li Y, Goodrich JM, Peterson KE, Song PX, Luo L.   +4 more
europepmc   +1 more source

Epigenetic Clocks Relate to 4 Age-related Health Outcomes Similarly Across 3 Countries. [PDF]

J Gerontol A Biol Sci Med Sci
Crimmins EM, Hernandez B, Potter C, Kim JK, Higgins-Chen A, Kenny RA, O'Halloran AM, McGuinness B, Smyth LJ, Hill C, Fiorito G, Faul J, McKnight AJ, McCrory C.   +13 more
europepmc   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

LinAge2: providing actionable insights and benchmarking with epigenetic clocks. [PDF]

NPJ Aging
Fong S, Denisov KA, Nefedova AA, Kennedy BK, Gruber J.   +4 more
europepmc   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

How does socio-economic position (SEP) get biologically embedded? A comparison of allostatic load and the epigenetic clock(s)

, 2019
Cathal McCrory, Giovanni Fiorito, Cliona Ní Cheallaigh, Silvia Polidoro, Piia Karisola, Harri Alenius, Richard Layte, Teresa E. Seeman, Paolo Vineis, Rose Anne Kenny   +9 more
openalex   +2 more sources

Discrimination, Coping, and DNAm Accelerated Aging Among African American Mothers of the InterGEN Study. [PDF]

Epigenomes
Nyembwe A, Zhao Y, Caceres BA, Belsky DW, Ryan CP, Taylor B, Morrison MT, Prescott L, Potts-Thompson S, Aziz A, Aruleba F, Matute-Arcos E, Williams O, Crusto C, Taylor JY.   +14 more
europepmc   +1 more source