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A mathematical description of biological clocks
Biosystems, 1967Abstract The implications of a concise mathematical formulation of the effect of light pulses on circadian rhythms are presented and discussed. The description is based on a model originally proposed by Pittendrigh.
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Aging and the Biological Clock
2017Aging and the biological clock are linked via metabolism. We explore how different pathways within metabolism link aging and the clock. These linking pathways include those involving: (1) sphingolipid metabolism; (2) the sir2 complex of genes affecting caloric restriction ; (3) pathways underlying oxidative stress ; (4) the cell cycle ; and (5) glucose
Jonathan Arnold +2 more
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Cryptochromes and biological clocks
Resonance, 2002Many of the biological activities of living organisms are light dependent and revolve around the solar clock. A variety of behaviours and physiological processes are under the control of internal biological clocks. These internal clocks are remarkably synchronized with the external solar clock (day-night cycle of 24 hour periodicity).
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Chronopharmacology Focused on Biological Clock
Drug Metabolism and Pharmacokinetics, 2007The mammalians circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN) and influences a multitude of biological processes, including the sleep-wake rhythm. Clock genes are the genes that control the circadian rhythms in physiology and behavior.
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Unclocklike behaviour of biological clocks
Nature, 1975The mechanisms which could underlie circadian rhythms fall naturally into groups with qualitatively different responses to disruption. Experiments designed to distinguish between these mechanisms seem to exclude all of them. It may be that multicellular organisms keep time, not by one ‘clock’ but by averaging many independent circadian oscillators.
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Biological Clocks and Their Synchronizers
1978Biological clocks are interpreted as self-sustained oscillations whose phase can be entrained by an external synchronizer. The prime synchronizer is light, but temperature may occasionally be effective. Other possible factors are also mentioned, and their operation discussed.
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2005
Most organisms living on earth have an internal clock and thus circadian rhythm represents a basic feature of life. The discovery of the mammalian clock genes and their oscillatory mechanisms have brought the research on biological clocks to a variety of fields of life science and medicine. In many organisms, the circadian core oscillator is thought to
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Most organisms living on earth have an internal clock and thus circadian rhythm represents a basic feature of life. The discovery of the mammalian clock genes and their oscillatory mechanisms have brought the research on biological clocks to a variety of fields of life science and medicine. In many organisms, the circadian core oscillator is thought to
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Science, 1957