Results 31 to 40 of about 72,901 (315)
Novel Epigenetic Clock Biomarkers of Age-Related Macular Degeneration
Frontiers in Medicine, 2022 Age-Related Macular Degeneration (AMD) is a bilateral ocular condition resulting in irreversible vision impairment caused by the progressive loss of photoreceptors in the macula, a region at the center of the retina. The progressive loss of photoreceptor
Saurav Mallik +5 more
doaj +1 more source
Formal Systems Architectures for Biology [PDF]
, 2011 When the word "systems" is used in systems biology, it invokes a variety of assumptions about what defines the subject under investigation, which in turn can lead to divergent research outcomes.
Bradly Alicea
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Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Clinical Epigenetics, 2023 Background The present study investigates whether epigenetic differences emerge in the heart of patients undergoing cardiac surgery for an aortic valvular replacement (AVR) or coronary artery bypass graft (CABG).
A. Mongelli +20 more
doaj +1 more source
In Synch but Not in Step: Circadian Clock Circuits Regulating Plasticity in Daily Rhythms [PDF]
, 2016 The suprachiasmatic nucleus (SCN) is a network of neural oscillators that program daily rhythms in mammalian behavior and physiology. Over the last decade much has been learned about how SCN clock neurons coordinate together in time and space to form a ...
Evans, Jennifer A., Gorman, M. R.
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Circadian and Geotactic Behaviors: Genetic Pleiotropy in Drosophila Melanogaster
Journal of Circadian Rhythms, 2016 Data presented in this paper test the hypotheses that Hirsch’s positive geotaxis ('Lo') and negative geotaxis ('Hi5') strains of Drosophila melanogaster (fruit fly) differ in length of the free-running circadian activity period (tau) as well as adult ...
Dale L Clayton
doaj +1 more source
Quantitative analysis of regulatory flexibility under changing environmental conditions [PDF]
, 2010 The circadian clock controls 24-h rhythms in many biological processes, allowing appropriate timing of biological rhythms relative to dawn and dusk. Known clock circuits include multiple, interlocked feedback loops.
Adrian W Thomson +12 more
core +4 more sources
Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions [PDF]
, 2015 A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes.
Arble, Deanna M +28 more
core +4 more sources
Light and circadian regulation of clock components aids flexible responses to environmental signals [PDF]
, 2014 The circadian clock measures time across a 24h period, increasing fitness by phasing biological processes to the most appropriate time of day. The interlocking feedback loop mechanism of the clock is conserved across species; however, the number of loops
Akman, Ozgur E +5 more
core +2 more sources
Biological clock: Biological clocks may modulate drug addiction [PDF]
European Journal of Human Genetics, 2005 A recent study by McClung's group (2005),1 expanding on an earlier report,2 provides mechanistic insight to the timekeeper gene, Clock, which may regulate dopaminergic transmission and cocaine reward. This work provides further evidence that cocaine-induced effects have circadian influences.
Vadim Yuferov +2 more
openaire +1 more source
Clinical Epigenetics, 2023 Background Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecular hallmarks such as epigenetic alterations and telomere attenuation reflect the biological process of aging. Epigenetic
Yosra Bejaoui +8 more
doaj +1 more source