Results 51 to 60 of about 64,785 (232)

Robustness of circadian clocks to daylight fluctuations: hints from the picoeucaryote Ostreococcus tauri [PDF]

, 2010
The development of systemic approaches in biology has put emphasis on identifying genetic modules whose behavior can be modeled accurately so as to gain insight into their structure and function.
A Goldbeter, A Goldbeter, Albert Goldbeter, AN Dodd, Benjamin Pfeuty, C Courties, C Troein, CS Pittendrigh, D Alabadi, D Gonze, D Rand, DA Rand, DB Forger, DGM Beersma, E Derelle, E Elowitz, E Hairer, F Corellou, F Geier, Florence Corellou, François-Yves Bouget, G Kurosawa, G Kurosawa, G Tiana, J Guckenheimer, J Moré, J Stricker, J Tomita, JC Leloup, JCW Locke, JCW Locke, JCW Locke, JD Salazar, L Ashall, L Rensing, LK Bognar, M Elowitz, M Merrow, M Moulager, MA Kramer, Marc Lefranc, MJ Chretiennot-Dinet, MN Zeilinger, N Barkai, NA Cookson, P Francois, P François, PE Morant, Pierre-Emmanuel Morant, Quentin Thommen, R Toth, S Panda, SR Taylor, TS Gardner, U Alon, W Mather, WW Wong, Y Ouyang, Y Shav-Tal   +58 more
core   +5 more sources

Biological Clocks and Ventricular Tachyarrhythmias

Journal of the American College of Cardiology, 2014
Sudden cardiac death (SCD) due to sustained ventricular tachyarrhythmias (VTA) remains a major public health problem because of poor understanding of the mechanisms. Initiation of VTA in animal models and in patients usually requires intense metabolic or electrical stimuli not often observed ...
openaire   +3 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Understanding the retardation of the returned astronaut's clock and GPS clocks using the physical behaviour of moving light clocks [PDF]

, 2007
The prediction of retardation of an astronaut’s clock during a round trip, compared to the clock of the stay-at-home, introduced by Einstein in his 1905 paper has been the most contentious issue for relativity.
McCarthy, Lance
core   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Biological clocks: The coming of age

International Journal of Applied and Basic Medical Research, 2012
Life evolved on earth slowly over a few billions of years. During this time, and before, the earth has been rotating around its own tilted axis and simultaneously revolving around the sun. Thus, it is no surprise that the periodic environmental consequences of the rotation (day and night), the tilt (changing day length) and of the revolution (seasons ...
openaire   +4 more sources