Results 111 to 120 of about 10,327,060 (336)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Fluctuation effects in bidirectional cargo transport

, 2014
We discuss a theoretical model for bidirectional cargo transport in biological cells, which is driven by teams of molecular motors and subject to thermal fluctuations.
Appert-Rolland, Cécile, Klein, Sarah, Santen, Ludger   +2 more
core   +3 more sources

Biological efficiently of cooked sausages protein

Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies, 2019
Food proteins, besides being used as sources of energy and providing the body with amino acids for the protein synthesis, are important biological objects that help maintain the overall health of a person, participate in the growth and development of the organism, and the functioning of cellular metabolism.
R Svyatnenko, V. Pasichnyi, I. Strashynskyi, O. Fursik   +3 more
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Maximum power operation of interacting molecular motors

, 2013
We study the mechanical and thermodynamic properties of different traffic models for kinesin which are relevant in biological and experimental contexts.
Golubeva, Natalia, Imparato, Alberto
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Enhancing Pleurotus ostreatus P. Kumm cultivation on peel of the fruit of Astrocaryum aculeatum (Jacq.) G. Mey by investigating the influence of moisture and supplementation with wheat bran [PDF]

Brazilian Journal of Biology
This study investigates the impact of moisture and wheat bran supplementation on the biological efficiency (BE) and nutritional profile of Pleurotus ostreatus (Jacq.) P. Kumm cultivated on peels of Astrocaryum aculeatum G. Mey.
K. M. Lotas, R. S. K. Fonseca, J. C. M. Costa, A. C. A. Cortez, F. C. A. Souza, F. S. Fernandes, J. F. V. Ennes, J. P. A. Silva, L. M. Carneiro, E. S. M. Canto, S. E. Zelski, J. V. B. Souza, E. S. Souza   +12 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Efficient estimation of energy transfer efficiency in light-harvesting complexes

, 2012
The fundamental physical mechanisms of energy transfer in photosynthetic complexes is not yet fully understood. In particular, the degree of efficiency or sensitivity of these systems for energy transfer is not known given their non-perturbative and non ...
A. Shabani, C. M. Van Vliet, H. Haken, H. Rabitz, H. van Amerongen, H.-P. Breuer, M. Mohseni, P. Reineker, R. G. Parr, S. Lloyd, S. Mukamel, S. Savikhin, V. M. Kenkre, V. May, W. Rugh   +14 more
core   +1 more source

GMB: An Efficient Query Processor for Biological Data

Journal of Integrative Bioinformatics, 2011
Summary Bioinformatics applications manage complex biological data stored into distributed and often heterogeneous databases and require large computing power. These databases are too big and complicated to be rapidly queried every time a user submits a query, due to the overhead involved in decomposing the queries, sending the decomposed queries to ...
Taha Kamal, Elmasri Ramez
openaire   +3 more sources