Results 101 to 110 of about 5,611,755 (345)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Non-equilibrium polymeric complex fluids
, 2011 Complex fluids are commercially- and industrially-important materials which exhibit ordering on scales much larger than atomic. Their usage is typically in non-equilibrium conditions, however traditional methods for measuring rheology are not appropriate
Willmer, D
core
Компьютерная оптикаThe need to develop a new reliable and easy-to-implement method for the real-time monitoring of parameters of biological fluids to solve various problems in medicine, biology and related fields is substantiated.
V.V. Davydov, D.V. Vakorina, O.S. Vezo
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Polyelectrolyte properties of filamentous biopolymers and their consequences in biological fluids
Soft Matter, 2014 Anionic polyelectrolyte filaments are common in biological cells. DNA, RNA, the cytoskeletal filaments F-actin, microtubules, and intermediate filaments, and polysaccharides such as hyaluronan that form the pericellular matrix all have large net negative
P. Janmey +4 more
semanticscholar +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2018 Rigid or flexible particles suspended in viscoelastic fluids are ubiquitous in the food industry (e.g. pastes), industrial molding applications (all composites and 3-D printed parts), the energy industry (e.g. fracking fluids), and biological fluids (i.e.
Shaqfeh, Eric
core
Oxysterolsulfates in fluids, cells and tissues: how much do we know about their clinical significance, biological relevance and biophysical implications? [PDF]
Oxysterol sulfates are emerging as key players in lipid homeostasis, inflammation and immunity. Despite this, knowledge on their basal levels in fluids, cells and tissues and any changes associated with age, gender and diet in health and disease; as well
Dias, Irundika, Reis, Ana
core +1 more source