Results 71 to 80 of about 863,191 (290)

Pseudouridine Chemical Labeling and Profiling

, 2015
Pseudouridine (Psi) is the most abundant posttranscriptional RNA modification; yet little is known about its prevalence and function in messenger RNA, mostly due to the challenges in the transcriptome-wide detection of Psi.
Xiaoyu Li, Li, Xiaoyu, Chengqi Yi, Yi, Chengqi, Ma, Shiqing, Shiqing Ma   +5 more
core   +1 more source

Local and regional rarity in a diverse tropical fish assemblage [PDF]

, 2012
Because most species in an ecological assemblage are rare, much of the species richness we value is due to taxa with few individuals or a restricted distribution.
Sobansky, M, Hercos, A. P., Hercos, A, Magurran, Anne, Queiroz, Helder Lima de, Magurran, Anne E., Queiroz, H, Sobansky, M.   +7 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Preparation, Characterization and Thermoplastic Analysis of Acetylated Starch with Different Substitution Degree

Shipin gongye ke-ji
In order to better apply starch as a polymer material in the material industry, it is necessary to modify starch. In this study, cassava starch was used as raw material, and it was pretreated and acetylated in an anhydrous medium.
Jingwen WANG, Jiahong DU, Xin LIU, Dingyu XU, Xianchao YAO, Rihui LIN   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Protein covalent modification of biologically active quinones [PDF]

Journal of the Serbian Chemical Society, 2004
The avarone/avarol quinone/hydroquinone couple shows considerable antitumor activity. In this work, covalent modification of ?-lactoglobulin by avarone and its derivatives as well as by the synthetic steroidal quinone 2,5(10)-estradiene- 1,4,17-trione and its derivatives were studied. The techniques for studying chemical modification of ?-lactoglobulin
Dusan Sladic, Irena Novakovic, Zoran Vujcic, Tatjana Bozic, Natasa Bozic, Dragan Milic, Bogdan Solaja, Miroslav Gasic   +7 more
openaire   +4 more sources

Role of Glycosyltransferases Modifying Type B Flagellin of Emerging Hypervirulent Clostridium difficile Lineages and Their Impact on Motility and Biofilm Formation. [PDF]

, 2016
Clostridium difficile is the principal cause of nosocomial infectious diarrhea worldwide. The pathogen modifies its flagellin with either a type A or type B O-linked glycosylation system, which has a contributory role in pathogenesis.
Dell, Anne, Donahue, Elizabeth, Wren, Brendan W, Morris, HR, Hitchen, Paul, Valiente, E, Dawson, LF, Panico, M, Songane, M, Dawson, Lisa F, Stabler, Richard A, Bajaj-Elliott, Mona, Morris, Howard R, Valiente, Esmeralda, Logan, SM, Wren, BW, Faulds-Pain, A, Logan, Susan M, Dell, A, Faulds-Pain, Alexandra, Bajaj-Elliott, M, Donahue, E, Songane, Mario, Bouche, L, Stabler, RA, Bouché, Laura, Panico, Maria, Hitchen, P   +27 more
core   +1 more source

DataSheet2_Characterization of Modification Patterns, Biological Function, Clinical Implication, and Immune Microenvironment Association of m6A Regulators in Pancreatic Cancer.CSV

, 2021
Objective: N6-methyladenosine (m6A) modification may modulate various biological processes. Nonetheless, clinical implications of m6A modification in pancreatic cancer are undefined.
Jiapei Wang (6851900), Desheng Tang (11447614), Changsheng Yan (2624530), Jiamin Ma (11413593), Kun Fang (619812), Hairong Qu (11447611), Lei Gao (6566)   +6 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source