Results 161 to 170 of about 1,240,733 (309)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Apple Products (Apple Juice and Cider) and By-Products (Apple Pomace): Bioactive Compounds and Biological Properties

Αλέξανδρος Τσούπρας, Despina A. Gkika, Theodoros Markopoulos, Roisin Curran, Ciara Scallon, Maria Karali, George Z. Kyzas   +6 more
openalex   +2 more sources

Evaluation of Chemical and Biological Products for Control of Crown Gall on Rose. [PDF]

Pathogens
Oksel C, Liyanapathiranage P, Parajuli M, Avin FA, Jennings C, Simmons T, Baysal-Gurel F.   +6 more
europepmc   +1 more source

Dosage of Anti-Canine Distemper Serum and Similar Biological Product

, 1965
Minoru Shinohara, Tomio HISAYAMA, Noboru FUJIE, Noboru Yamada   +3 more
openalex   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Chemical composition, biological activities and product development of Gastrodia elata : a review [PDF]

Yuchen Jiang, Wen Lian-kui, Wenqi Wang, Rongchen Zhu, Jiahua Liu, Yang He, Fei Zheng, Yuzhu Wu   +7 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Mechanistic Exploration of Yiqi Zengmian in Regulating the Microenvironment as an Immunopotentiator with the Beijing Bio-Institute of Biological Products Coronavirus Vaccine Based on Transcriptomics and Integrated Serum Pharmacochemistry. [PDF]

Pharmaceuticals (Basel)
Yu Z, Wang Y, Sun J, Zheng X, Hao L, Deng Y, Li J, Li Z, Shan Z, Li W, Qiao Y, Huo R, Xiong Y, Huo H, Li H, Lin L, Huang H, Liu G, Wang A, Li H, Huang L.   +20 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Decentralized Clinical Trials in the Development of Drugs and Biological Products. [PDF]

Ther Innov Regul Sci
Robinson R, Sacks L.
europepmc   +1 more source