Results 41 to 50 of about 2,638,691 (365)

Bisaurones – enzymatic production and biological evaluation [PDF]

New Journal of Chemistry, 2020
The enzyme-catalyzed oxidation of butein afforded four dimers of aurone sulfuretin with cytotoxic and antioxidative properties.
Miroslav Novakovic, Tatjana Ilic-Tomic, Vele Tesevic, Katarina Simic, Stefan Ivanovic, Stefan Simic, Igor Opsenica, Jasmina Nikodinovic-Runic   +7 more
openaire   +6 more sources

An mRNA-based broad-spectrum vaccine candidate confers cross-protection against heterosubtypic influenza A viruses

Emerging Microbes and Infections, 2023
Influenza virus is a prominent cause of respiratory illness in humans. Current influenza vaccines offer strain-specific immunity, while provide limited protection against drifted strains.
Feifei Xiong, Chi Zhang, Baoyuan Shang, Mei Zheng, Qi Wang, Yahong Ding, Jian Luo, Xiuling Li   +7 more
doaj   +1 more source

Mining microbial genomes for new natural products and biosynthetic pathways [PDF]

, 2008
Analyses of microbial genome sequences have revealed numerous examples of ‘cryptic’ or ‘orphan’ biosynthetic gene clusters, with the potential to direct the production of novel, structurally complex natural products.
Austin, Austin, Banskota, Banskota, Barona-Gómez, Barona-Gómez, Bentley, Bergmann, Bok, Caffrey, Chain, Challis, Challis, Challis, Challis, Chen, Chen, Corre, de Bruijn, Drake, Erb, Fischbach, Fleischmann, Fleming, Funa, Gregory L. Challis, Gross, Gross, Grüschow, Gust, Günter, Haydock, Haynes, Hojati, Hornung, Ikeda, Izumikawa, Kadi, Keller, Koehn, Larsen, Lautru, Lautru, Li, Li, Lin, Lin, McAlpine, Miethke, Minowa, Miyanaga, Muller, Nguyen, Oliynyk, Omura, Paulsen, Petersen, Pfeifer, Rausch, Reid, Song, Stachelhaus, Sudek, Tohyama, Udwary, Wilkinson, Zhao, Zirkle   +67 more
core   +1 more source

Large-scale Biological Meta-database Management [PDF]

, 2015
Up-to-date meta-databases are vital for the analysis of biological data. However,the current exponential increase in biological data leads to exponentially increasing meta-database sizes. Large-scale meta-database management is therefore an important challenge for production platforms providing services for biological data analysis.
arxiv   +1 more source

Processive and Distributive Non-Equilibrium Networks Discriminate in Alternate Limits [PDF]

J. Stat. Mech. 2022, 083206 (2022), 2020
We study biochemical reaction networks capable of product discrimination inspired by biological proofreading mechanisms. At equilibrium, product discrimination, the selective formation of a "correct" product with respect to an "incorrect product", is fundamentally limited by the free energy difference between the two products.
arxiv   +1 more source

Copper-containing mesoporous bioactive glass promotes angiogenesis in an in vivo zebrafish model [PDF]

, 2017
The osteogenic and angiogenic responses of organisms to the ionic products of degradation of bioactive glasses (BGs) are being intensively investigated. The promotion of angiogenesis by copper (Cu) has been known for more than three decades. This element
Aguiar, Arkudas, Aránzazu Díaz-Cuenca, Chang, Childs, Craig, Cui, Day, Dooley, Garcia-Olmo, García-Vilas, Geissberger, Gerhardt, Goi, Goldberg, González, Gorustovich, Gospodarowicz, Griffitt, Hagemann, Handel, Hench, Hench, Hoppe, Hu, Kari, Kong, Lawson, Li, Li, Lilian B. Romero-Sánchez, Manuel Marí-Beffa, Martin, Mckeown, Melet, Miguel Ángel Medina, Montazerolghaem, Naderi, Neumann, Oliveira, Paloma Carrillo, Parng, Perez, Pérez-Robles, Rahaman, Raju, Ramiro-Gutiérrez, Ramiro-Gutiérrez, Rath, Romero-Sánchez, Schuermann, Sen, Shing, Soncin, Staton, Stähli, Subbiah, Thomas, Thompson, Tienderson, Urso, Vallet-Regí, Vallet-Regí, Wang, Wu, Wu, Wu, Xia, Xiao, Xynos, Yan, Zhai   +71 more
core   +2 more sources

Artificial intelligence and biological misuse: Differentiating risks of language models and biological design tools [PDF]

arXiv, 2023
As advancements in artificial intelligence (AI) propel progress in the life sciences, they may also enable the weaponisation and misuse of biological agents. This article differentiates two classes of AI tools that could pose such biosecurity risks: large language models (LLMs) and biological design tools (BDTs). LLMs, such as GPT-4 and its successors,
arxiv  

Reporter Coxsackievirus A5 Expressing iLOV Fluorescent Protein or Luciferase Used for Rapid Neutralizing Assay in Cells and Living Imaging in Mice

Viruses, 2023
Coxsackievirus A5 (CV-A5) is a re-emerging enterovirus that causes hand, foot, and mouth disease in children under five years of age. CV-A5-M14-611 is a mouse-adapted strain that can infect orally and lead to the death of 14-day-old mice.
Wei-Ping Jin, Chen Wang, Jie Wu, Jing Guo, Sheng-Li Meng, Ze-Jun Wang, Dai-Guan Yu, Shuo Shen   +7 more
doaj   +1 more source

Research Advances on the Stability of mRNA Vaccines

Viruses, 2023
Compared to other vaccines, the inherent properties of messenger RNA (mRNA) vaccines and their interaction with lipid nanoparticles make them considerably unstable throughout their life cycles, impacting their effectiveness and global accessibility.
Feiran Cheng, Yiping Wang, Yu Bai, Zhenglun Liang, Qunying Mao, Dong Liu, Xing Wu, Miao Xu   +7 more
doaj   +1 more source

Real-Time Interactive Modeling and Simulation in Biological Physics and Active Matter with Mechanica [PDF]

arXiv, 2021
Modeling and simulation (M&S) has revolutionized the way modern engineered products are designed, tested and evaluated. Yet modeling and simulation is much less frequently applied in the study of natural biological and active matter systems. Two of the greatest challenges in applying M\&S approaches to natural biological systems are (1) difficulty in ...
arxiv