Results 41 to 50 of about 1,240,733 (309)

Immunogenicity and safety in animals of a lyophilized live attenuated hepatitis A vaccine following stabilizer optimization

Scientific Reports
To evaluate the immunogenicity and safety profiles of lyophilized hepatitis A live attenuated vaccine (L-A-1 attenuated strain) after stabilizer formula optimization using non-human primates and various rodent models.
Yibo Wang, Qingjuan Xia, Chunlei Li, Peng Wu, Liguang Yue, Xinlei Wang, Ge Bai, Shujun Zheng, Yanling Xu   +8 more
doaj   +1 more source

Measles Virus-Based Vaccine Expressing Membrane-Anchored Spike of SARS-CoV-2 Inducing Efficacious Systemic and Mucosal Humoral Immunity in Hamsters

Viruses
As SARS-CoV-2 continues to evolve and COVID-19 cases rapidly increase among children and adults, there is an urgent need for a safe and effective vaccine that can elicit systemic and mucosal humoral immunity to limit the emergence of new variants.
Zhi-Hui Yang, Yan-Li Song, Jie Pei, Song-Zhuang Li, Rui-Lun Liu, Yu Xiong, Jie Wu, Yuan-Lang Liu, Hui-Fen Fan, Jia-Hui Wu, Ze-Jun Wang, Jing Guo, Sheng-Li Meng, Xiao-Qi Chen, Jia Lu, Shuo Shen   +15 more
doaj   +1 more source

Genome sequence of Bovine Ephemeral fever virus vaccine strain of South African origin

Veterinary Medicine and Science, 2021
Bovine Ephemeral fever virus (BEFV) is endemic in South Africa and has a negative economic impact on the meat and dairy industries. Bovine ephemeral fever or three‐day stiff‐sickness is controlled through annual vaccination with a live attenuated virus ...
Tendai A. M. Mlingo, Bethuel M. Nthangeni, Nobalanda B. Mokoena   +2 more
doaj   +1 more source

Systematic Evaluation of the Distribution of Immune Cells following Subcutaneous Administration of Haemophilus Influenzae Type B Vaccine to Mice

Diseases, 2023
The Haemophilus influenzae type B (Hib) conjugate vaccine is the most effective way to prevent Hib infection in infants and young children, and it is designed to induce the production of antibodies against polyribosylribitol phosphate (PRP) to protect ...
Yao He, Yuxiu Zhao, Hongyang Liang, Xue Wang, Haoyue Lan, Dongyang Tian, Yan Li, Hui Wang   +7 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Physicochemical properties and adsorption state of aluminum adjuvants with different processes in vaccines

Heliyon, 2023
Aluminum salts are by far the most widely used adjuvants for human vaccines, showing acceptable safety and efficacy. Previous studies have shown that each aluminum adjuvant have different charges and morphologies, but whether the manufacturing and ...
Cunpei Bo, Xiaoli Wei, Xue Wang, Wenheng Ji, Huan Yang, Yuxiu Zhao, Hui Wang   +6 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Evaluation of Stability, Inactivation, and Disinfection Effectiveness of Mpox Virus

Viruses
Background: Mpox virus (MPXV) infections have increased in many countries since May 2022, increasing demand for diagnostic tests and research on the virus.
Yuwei Li, Shiyun Lv, Yan Zeng, Zhuo Chen, Fei Xia, Hao Zhang, Demiao Dan, Chunxia Hu, Yi Tang, Qiao Yang, Yaqi Ji, Jia Lu, Zejun Wang   +12 more
doaj   +1 more source

Identification of Critical Amino Acids of Coxsackievirus A10 Associated with Cell Tropism and Viral RNA Release during Uncoating

Viruses, 2023
Coxsackievirus A10 (CV-A10) is a prevailing causative agent of hand–foot–mouth disease, necessitating the isolation and adaptation of appropriate strains in cells allowed for human vaccine development.
Jie Pei, Rui-Lun Liu, Zhi-Hui Yang, Ya-Xin Du, Sha-Sha Qian, Sheng-Li Meng, Jing Guo, Bo Zhang, Shuo Shen   +8 more
doaj   +1 more source