Results 61 to 70 of about 10,008,274 (374)

Safety, dosing, and pharmaceutical quality for studies that evaluate medicinal products (including biological products) in neonates

Pediatric Research, 2017
The study of medications among pediatric patients has increased worldwide since 1997 in response to new legislation and regulations, but these studies have not yet adequately addressed the therapeutic needs of neonates.
R. Ward, D. Benjamin, J. Barrett, K. Allegaert, R. Portman, J. Davis, M. Turner   +6 more
semanticscholar   +1 more source

Network topology drives population temporal variability in experimental habitat networks

Population Ecology, EarlyView.
Habitat patches connected by dispersal pathways form habitat networks. We explored how network topology affects population outcomes in laboratory experiments using a model species (Daphnia carinata). Central habitat nodes in complex lattice networks exhibited lower temporal variability in population sizes, suggesting they support more stable ...
Yiwen Xu, J. Angus Webb, William D. Bovill, Elise L. King   +3 more
wiley   +1 more source

Slim and scum: Natural products from land and sea [PDF]

, 2000
To a natural-products chemist, the term "natural products" does not refer to all compounds from natural sources, as the name might imply. It is specifically used to refer to compounds known as secondary metabolites, structurally complex molecules, often ...
Prinsep, Michèle R.
core   +1 more source

Biosynthesis of thiocarboxylic acid-containing natural products. [PDF]

, 2018
Thiocarboxylic acid-containing natural products are rare and their biosynthesis and biological significance remain unknown. Thioplatensimycin (thioPTM) and thioplatencin (thioPTN), thiocarboxylic acid congeners of the antibacterial natural products ...
Deng, Youchao, Dong, Liao-Bin, Duan, Yanwen, He, Cyndi Qixin, Houk, KN, Huang, Yong, Kang, Dingding, Rudolf, Jeffrey D, Shen, Ben, Wang, Nan   +9 more
core   +1 more source

Application prospects of the 2BS cell-adapted China fixed rabies virus vaccine strain 2aG4-B40

Virology Journal
Background Rabies is a fatal zoonotic disease whose pathogenesis has not been fully elucidated, and vaccination is the only effective method for protecting against rabies virus infection. Most inactivated vaccines are produced using Vero cells, which are
Ying Xu, Lin Weng, Xuan Wang, Ming Li, Wanping Guo, Yiqing Liu, Xiang Li, Zhenping Wang, Xinyu Liu, Shengnan Xu, Feide He, Qianqian Hou, Tengzhou Li, Wenke Du, Yabo Zhang, Shumin Chang, Liwen Zhang, Yuntao Zhang   +17 more
doaj   +1 more source

WHO standards for biotherapeutics, including biosimilars: an example of the evaluation of complex biological products

Annals of the New York Academy of Sciences, 2017
The most advanced regulatory processes for complex biological products have been put in place in many countries to provide appropriate regulatory oversight of biotherapeutic products in general, and similar biotherapeutics in particular.
I. Knezevic, E. Griffiths
semanticscholar   +1 more source

Chemical and Biological Production of Cyclotides [PDF]

, 2015
Cyclotides are fascinating naturally occurring micro-proteins (≈30 residues long) present in several plant families, and display various biological properties such as protease inhibitory, anti-microbial, insecticidal, cytotoxic, anti-HIV and hormone-like activities.
Julio A. Camarero, Tao Bi, Yilong Li
openaire   +2 more sources

Geographic variation in walking activity in the red flour beetle Tribolium castaneum

Population Ecology, EarlyView.
This study examined whether there is geographic variation in field populations, focusing on the moving activity in the red flour beetle Tribolium castaneum. Results showed significant differences in moving activity among field populations but no correlation with latitude or meteorological factors.
Kentarou Matsumura
wiley   +1 more source

Mining microbial genomes for new natural products and biosynthetic pathways [PDF]

, 2008
Analyses of microbial genome sequences have revealed numerous examples of ‘cryptic’ or ‘orphan’ biosynthetic gene clusters, with the potential to direct the production of novel, structurally complex natural products.
Austin, Austin, Banskota, Banskota, Barona-Gómez, Barona-Gómez, Bentley, Bergmann, Bok, Caffrey, Chain, Challis, Challis, Challis, Challis, Chen, Chen, Corre, de Bruijn, Drake, Erb, Fischbach, Fleischmann, Fleming, Funa, Gregory L. Challis, Gross, Gross, Grüschow, Gust, Günter, Haydock, Haynes, Hojati, Hornung, Ikeda, Izumikawa, Kadi, Keller, Koehn, Larsen, Lautru, Lautru, Li, Li, Lin, Lin, McAlpine, Miethke, Minowa, Miyanaga, Muller, Nguyen, Oliynyk, Omura, Paulsen, Petersen, Pfeifer, Rausch, Reid, Song, Stachelhaus, Sudek, Tohyama, Udwary, Wilkinson, Zhao, Zirkle   +67 more
core   +2 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source