Results 101 to 110 of about 3,239,321 (318)

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

Advanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich, Jing Wang, Ferdinand Althammer, Tim Schubert, Nina Kluck, Valery Grinevich, Stefanie Schmitteckert, Christian P. Schaaf, Gudrun A. Rappold   +8 more
wiley   +1 more source

Diversity, Equity, and Inclusivity in Biological Psychiatry Research. [PDF]

Biol Psychiatry Cogn Neurosci Neuroimaging, 2022
Eckstrand KL, Singh MK, Ajilore O.
europepmc   +1 more source

Counterbalancing O‐GlcNAcylation and STAT3 Phosphorylation in Ventral Tegmental Area Dopaminergic Neurons Mediates Behavioral Adaptations to Acute Restraint Stress

Advanced Science, EarlyView.
Acute restraint stress enhances STAT3Ser727 phosphorylation in dopaminergic neurons in mice. This modification promotes the upregulation of GABBR2 and GABRB3, reduces neuronal activity, and contributes to anxiety‐like behavior and diminished reward‐seeking following stress exposure.
Mingshuo Shao, Yi Wu, Haiyang Wang, Chenchun Zhang, Ying Zhu, Yan Jiang, Changyou Jiang, Qiumin Le, Xing Liu, Lan Ma, Feifei Wang   +10 more
wiley   +1 more source

BIOLOGICAL CLOCKS IN MEDICINE AND PSYCHIATRY: SHOCK-PHASE HYPOTHESIS [PDF]

, 1960
Curt P. Richter
openalex   +1 more source

Aligning digital biomarker definitions in psychiatry with the National Institute of Mental Health Research Domain Criteria framework

NPP-Digital Psychiatry and Neuroscience
The field of biological psychiatry faces a growing influx of digital biomarkers spanning self-report, social, behavioral, cognitive, and physiological indicators of various mental health conditions.
Shai Mulinari
doaj   +1 more source

Holism is central to psychiatric practice

Kerala Journal of Psychiatry
Psychiatry in Kerala has come a long way from its humble beginnings. But, in the olden days, psychiatry practice used to be different; it was more holistic. Now, the focus is more on biological insights and novel technologies.
James T Antony
doaj   +1 more source

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

Advanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria, Cristina Iglesias, Sascha Jung, Javier Arcos Hodar, Ruben Nogueiras, Antonio del Sol   +5 more
wiley   +1 more source

Integration of Equity and Diversity Frameworks to Advance Biological Psychiatry. [PDF]

Biol Psychiatry Cogn Neurosci Neuroimaging, 2022
Arredondo MM, Garcini LM, McLaughlin KA.
europepmc   +1 more source

Books and Monographs: Biological Psychiatry [PDF]

, 1968
Jack Price
openalex   +1 more source

Challenges and Future Prospects of Precision Medicine in Psychiatry

Pharmacogenomics and Personalized Medicine, 2020
Mirko Manchia,1– 3,* Claudia Pisanu,4,* Alessio Squassina,4,5 Bernardo Carpiniello1,2 1Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy; 2Unit of Clinical Psychiatry, University ...
Manchia M, Pisanu C, Squassina A, Carpiniello B   +3 more
doaj