Results 1 to 10 of about 3,907,070 (256)

Artificial Intelligence in Biological Sciences. [PDF]

open access: yesLife (Basel), 2022
Artificial intelligence (AI), currently a cutting-edge concept, has the potential to improve the quality of life of human beings. The fields of AI and biological research are becoming more intertwined, and methods for extracting and applying the information stored in live organisms are constantly being refined.
Bhardwaj A, Kishore S, Pandey DK.
europepmc   +4 more sources

Redox-responsive polyurethane-polyurea nanoparticles targeting to aortic endothelium and atherosclerosis

open access: yesiScience, 2022
Summary: Aortic endothelial cell dysfunction is an early trigger of atherosclerosis, the major cause of the cardiovascular disease (CVD). Nanomedicines targeting vascular endothelium and lesions hold great promise as therapeutic solutions to vascular ...
Yuxiang Zhou   +9 more
doaj   +1 more source

Influence of data sampling methods on the representation of neural spiking activity in vivo

open access: yesiScience, 2022
Summary: In vivo single-unit recordings distinguish the basal spiking properties of neurons in different experimental settings and disease states. Here, we examined over 300 spike trains recorded from Purkinje cells and cerebellar nuclei neurons to test ...
Meike E. van der Heijden   +2 more
doaj   +1 more source

The RBPMSCreERT2-tdTomato mouse line for studying retinal and vascular relevant diseases

open access: yesiScience, 2023
Summary: RNA-binding protein with multiple splicing (RBPMS) plays a crucial role in cardiac mesoderm specification and cardiovascular development, as well as being a typical marker for whole retinal ganglion cells (RGCs).
Guilan Li   +6 more
doaj   +1 more source

Top-down reconfiguration of SMA cortical connectivity during action preparation

open access: yesiScience, 2023
Summary: The Bereitschaftspotential (BP), a scalp potential recorded in humans during action preparation, is characterized by a slow amplitude increase over fronto-central regions as action execution approaches.
Valentina Bianco   +4 more
doaj   +1 more source

Conditions for maintenance of hepatocyte differentiation and function in 3D cultures

open access: yesiScience, 2021
Summary: Spheroid cultures of primary human hepatocytes (PHH) are used in studies of hepatic drug metabolism and toxicity. The cultures are maintained under different conditions, with possible confounding results. We performed an in-depth analysis of the
Niklas Handin   +10 more
doaj   +1 more source

Metabolic regulation of CTCF expression and chromatin association dictates starvation response in mice and flies

open access: yesiScience, 2023
Summary: Coordinated temporal control of gene expression is essential for physiological homeostasis, especially during metabolic transitions. However, the interplay between chromatin architectural proteins and metabolism in regulating transcription is ...
Devashish Sen   +10 more
doaj   +1 more source

Whole-brain optical access in a small adult vertebrate with two- and three-photon microscopy

open access: yesiScience, 2022
Summary: Although optical microscopy has allowed scientists to study the entire brain in early developmental stages, access to the brains of live, adult vertebrates has been limited.
Najva Akbari   +5 more
doaj   +1 more source

The Rigor and Transparency Index Quality Metric for Assessing Biological and Medical Science Methods

open access: yesiScience, 2020
Summary: The reproducibility crisis is a multifaceted problem involving ingrained practices within the scientific community. Fortunately, some causes are addressed by the author's adherence to rigor and reproducibility criteria, implemented via ...
Joe Menke   +4 more
doaj   +1 more source

Evidence for a two-step model of social group influence

open access: yesiScience, 2022
Summary: Social group influence plays an important role in societally relevant phenomena such as rioting and mass panic. One way through which groups influence individuals is by directing their gaze. Evidence that gaze following increases with group size
Emiel Cracco   +7 more
doaj   +1 more source

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