Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators [PDF]
, 2016 This Letter was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) and the Scottish Universities Life Sciences Alliance (SULSA) in 2011Peer ...
Abdelrahman, Mostafa Hamed +4 more
core +1 more source
The ex vivo pharmacology of HIV-1 antiretrovirals differs between macaques and humans
iScience, 2022 Summary: Non-human primates (NHP) are widely used for the pre-clinical assessment of antiretrovirals (ARVs) for HIV treatment and prevention. However, the utility of these models is questionable given the differences in ARV pharmacology between humans ...
Carolina Herrera +12 more
doaj +1 more source
Systems biology in animal sciences [PDF]
, 2011 Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract ...
Bannink, A. +4 more
core +3 more sources
Circulating tumor cells: Towards mechanical phenotyping of metastasis
iScience, 2022 Summary: During cancer progression, metastatic dissemination accounts for ∼90% of death in patients. Metastasis occurs upon dissemination of circulating tumor cells (CTC) through body fluids, in particular the bloodstream, and several key steps remain ...
Marina Peralta +2 more
doaj +1 more source
Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates [PDF]
, 2014 BB/H012494/1/ Biotechnology and Biological Sciences Research ...
Barg E +10 more
core +3 more sources
iScience, 2022 Summary: We developed a workflow using multi-scale and multi-disciplinary experimental and computational approaches to analyze C-looping (the first phase of cardiac looping) of the chick across four developing hearts. We provide the first 3D datasets for
Nazanin Ebrahimi +5 more
doaj +1 more source
Imaging mass cytometry reveals the prominent role of myeloid cells at the maternal-fetal interface
iScience, 2022 Summary: Although the immunological complexity of the maternal-fetal interface is well appreciated, the actual interaction of maternal immune cells and fetal trophoblasts is insufficiently understood. To comprehend the composition and spatial orientation
Juliette Krop +18 more
doaj +1 more source
Nano-Size Layered Manganese-Calcium Oxide as an Efficient and Biomimetic Catalyst for Water Oxidation Under Acidic Conditions: Comparable To Platinum [PDF]
, 2013 Inspired by Nature's catalyst, a nano-size layered manganese-calcium oxide showed a low overvoltage for water oxidation in acidic solutions, which is comparable to platinum.Institute for Advanced Studies in Basic Sciences and the National Elite ...
Allakhverdiev, Suleyman I. +8 more
core +2 more sources
The dynamic action of SecA during the initiation of protein translocation [PDF]
, 2013 Biotechnology and Biological Sciences Research Council (BBSRC) [a doctoral training grant Ph.D. studentship to S.W. and project grant number BB/I008675/1] and the Wellcome Trust [project grant number 084452]
Alice Robson +30 more
core +2 more sources
Biophysical models accurately characterize the thermal energetics of a small invasive passerine bird
iScience, 2023 Summary: Effective management of invasive species requires accurate predictions of their invasion potential in different environments. By considering species’ physiological tolerances and requirements, biophysical mechanistic models can potentially ...
Marina Sentís +5 more
doaj +1 more source