Results 101 to 110 of about 3,926,185 (357)

Sex difference in liver diseases: How preclinical models help to dissect the sex-related mechanisms sustaining NAFLD and hepatocellular carcinoma

iScience, 2023
Summary: Only a few preclinical findings are confirmed in the clinic, posing a critical issue for clinical development. Therefore, identifying the best preclinical models can help to dissect molecular and mechanistic insights into liver disease ...
Alfredo Smiriglia, Nicla Lorito, Marina Serra, Andrea Perra, Andrea Morandi, Marta Anna Kowalik   +5 more
doaj  

Characteristics of the North American flora; an address to the botanists of the British Association for the Advancement of Science at Montreal; read to the Biological Section [PDF]

, 1884
Asa Gray
openalex   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Modeling Biological Problems in Computer Science: A Case Study in Genome Assembly [PDF]

arXiv, 2017
As computer scientists working in bioinformatics/computational biology, we often face the challenge of coming up with an algorithm to answer a biological question. This occurs in many areas, such as variant calling, alignment, and assembly. In this tutorial, we use the example of the genome assembly problem to demonstrate how to go from a question in ...
arxiv  

THE BIOLOGICAL SECTION OF THE ACADEMY OF SCIENCE AND ART OF PITTSBURGH, PA [PDF]

, 1903
Frank Webster
openalex   +1 more source

Potentiality in Biology [PDF]

, 2018
We take the potentialities that are studied in the biological sciences (e.g., totipotency) to be an important subtype of biological dispositions. The goal of this paper is twofold: first, we want to provide a detailed understanding of what biological ...
A Bird, A Hüttemann, A Hüttemann, AC Love, B Alberts, CF Craver, CF Craver, CF Craver, CR Townsend, D Lewis, DH Mellor, E Prior, G Molnar, J Frydman, J Mackie, J McKitrick, J Woodward, KF Schaffner, L Darden, L Darden, M Kirschner, N Cartwright, NA Campbell, P Machamer, R Carnap, RN Brandon, RN Brandon, S Glennan, S Mumford, S Mumford, SC Stearns, SD Mitchell, SD Mitchell, SF Gilbert, SK Mills, T Handfield, W Bechtel, W Bechtel   +37 more
core   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Cytoplasmic delivery of antibodies through grafting a functional single complementarity‐determining region loop

FEBS Letters, EarlyView.
We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon, Juho Choi, Youngin Roh, Eunbin Lee, Luigie Villamante, Myung‐Hee Kwon   +5 more
wiley   +1 more source

State of basin report : status of blue crabs in South Carolina [PDF]

, 2011
This newsletter updates the public about blue crab research in the ACE Basin NERRand is a source of information regarding the life-history, ecology and behavior of blue crabs.
Clemson University. Department of Biological Sciences
core   +3 more sources