Results 81 to 90 of about 3,926,185 (357)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Growing South Dakota (Fall 2010) [PDF]

open access: yes, 2010
[Page] 2 Focused on Lean Growth: Despite Challenging Times, Dean Barry Dunn Has a Vision of Growth and Excellence for ABS [Page] 6 Building Better Communities: Horizons Helps Small Town South Dakota[Page] 8 On Campus [Page] 9 Urban Opportunities: A New ...
Biological Sciences, College of Agriculture &
core   +4 more sources

The Encyclopaedia of the Biological Sciences

open access: yesSoil Science, 1961
Includes bibliographies and index. ; Includes bibliographies. ; Mode of access: Internet.
openaire   +2 more sources

South Dakota Thriving, Fall 2009 [PDF]

open access: yes, 2009
Table of Contents: [Page] 2 Growing Farmers Markets: South Dakota Cooperative Extension Service Helps Develop and Grow Booming Homegrown markets [Page] 4 Lighari Leads Restructuring of Extension: Director of South Dakota Cooperative Extension Service ...
Biological Sciences, College of Agriculture &
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

Loss-of-function variants in KCTD19 cause non-obstructive azoospermia in humans

open access: yesiScience, 2023
Summary: Azoospermia is a significant cause of male infertility, with non-obstructive azoospermia (NOA) being the most severe type of spermatogenic failure.
Junyan Liu   +24 more
doaj  

Proceedings of the 5th Workshop on Membrane Computing and Biologically Inspired Process Calculi (MeCBIC 2011) [PDF]

open access: yesarXiv, 2011
This volume represents the proceedings of the 5th Workshop on Membrane Computing and Biologically Inspired Process Calculi (MeCBIC 2011), held together with the 12th International Conference on Membrane Computing on 23rd August 2011 in Fontainebleau, France.
arxiv  

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

open access: yesFEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti   +3 more
wiley   +1 more source

Biophysical models accurately characterize the thermal energetics of a small invasive passerine bird

open access: yesiScience, 2023
Summary: Effective management of invasive species requires accurate predictions of their invasion potential in different environments. By considering species’ physiological tolerances and requirements, biophysical mechanistic models can potentially ...
Marina Sentís   +5 more
doaj  

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