Results 11 to 20 of about 317,941 (266)
iScience, 2022 Summary: The United States Environmental Protection Agency (EPA) has been pursuing new high throughput in vitro assays to characterize endocrine disrupting chemicals (EDCs) that interact with estrogen receptor signaling.
Adam T. Szafran +3 more
doaj +1 more source
iScience, 2023 Summary: Metastatic lesions produced through the process of systemic tumor cell dissemination and growth at distant sites are challenging to treat and the primary cause of patient mortality.
Sumreen Javed +4 more
doaj +1 more source
Single-Cell RNA Sequencing for Plant Research: Insights and Possible Benefits
International Journal of Molecular Sciences, 2022 In recent years, advances in single-cell RNA sequencing (scRNA-seq) technologies have continued to change our views on biological systems by increasing the spatiotemporal resolution of our analysis to single-cell resolution.
G. Bawa +4 more
semanticscholar +1 more source
Influence of data sampling methods on the representation of neural spiking activity in vivo
iScience, 2022 Summary: In vivo single-unit recordings distinguish the basal spiking properties of neurons in different experimental settings and disease states. Here, we examined over 300 spike trains recorded from Purkinje cells and cerebellar nuclei neurons to test ...
Meike E. van der Heijden +2 more
doaj +1 more source
Artificial Intelligence: The Milestone in Modern Biomedical Research
BioMedInformatics, 2022 In recent years, the advent of new experimental methodologies for studying the high complexity of the human genome and proteome has led to the generation of an increasing amount of digital information, hence bioinformatics, which harnesses computer ...
Konstantina Athanasopoulou +3 more
semanticscholar +1 more source
The ex vivo pharmacology of HIV-1 antiretrovirals differs between macaques and humans
iScience, 2022 Summary: Non-human primates (NHP) are widely used for the pre-clinical assessment of antiretrovirals (ARVs) for HIV treatment and prevention. However, the utility of these models is questionable given the differences in ARV pharmacology between humans ...
Carolina Herrera +12 more
doaj +1 more source
Integrative processing of untargeted metabolomic and lipidomic data using MultiABLER
iScience, 2023 Summary: Mass spectrometry (MS)-based untargeted metabolomic and lipidomic approaches are being used increasingly in biomedical research. The adoption and integration of these data are critical to the overall multi-omic toolkit.
Ian C.H. Lee +4 more
doaj +1 more source
Mapping-friendly sequence reductions: Going beyond homopolymer compression
iScience, 2022 Summary: Sequencing errors continue to pose algorithmic challenges to methods working with sequencing data. One of the simplest and most prevalent techniques for ameliorating the detrimental effects of homopolymer expansion/contraction errors present in ...
Luc Blassel, Paul Medvedev, Rayan Chikhi
doaj +1 more source
Current Research on Silver Nanoparticles: Synthesis, Characterization, and Applications
, 2021 Over the past couple of decades, nanomaterials have advanced the research in materials; biomedical, biological, and chemical sciences; etc., owing to their peculiar properties at the nanoregime compared to their bulk composition.
Sonika Dawadi +8 more
semanticscholar +1 more source
Physical and chemical mechanisms of tissue optical clearing
iScience, 2021 Summary: Advanced optical methods combined with various probes pave the way toward molecular imaging within living cells. However, major challenges are associated with the need to enhance the imaging resolution even further to the subcellular level for ...
Tingting Yu +3 more
doaj +1 more source