Results 11 to 20 of about 100,345 (222)
The ex vivo pharmacology of HIV-1 antiretrovirals differs between macaques and humans
iScience, 2022 Summary: Non-human primates (NHP) are widely used for the pre-clinical assessment of antiretrovirals (ARVs) for HIV treatment and prevention. However, the utility of these models is questionable given the differences in ARV pharmacology between humans ...
Carolina Herrera +12 more
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Integrative processing of untargeted metabolomic and lipidomic data using MultiABLER
iScience, 2023 Summary: Mass spectrometry (MS)-based untargeted metabolomic and lipidomic approaches are being used increasingly in biomedical research. The adoption and integration of these data are critical to the overall multi-omic toolkit.
Ian C.H. Lee +4 more
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Mapping-friendly sequence reductions: Going beyond homopolymer compression
iScience, 2022 Summary: Sequencing errors continue to pose algorithmic challenges to methods working with sequencing data. One of the simplest and most prevalent techniques for ameliorating the detrimental effects of homopolymer expansion/contraction errors present in ...
Luc Blassel, Paul Medvedev, Rayan Chikhi
doaj +1 more source
Physical and chemical mechanisms of tissue optical clearing
iScience, 2021 Summary: Advanced optical methods combined with various probes pave the way toward molecular imaging within living cells. However, major challenges are associated with the need to enhance the imaging resolution even further to the subcellular level for ...
Tingting Yu +3 more
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Acoustic camera system for measuring ultrasound communication in mice
iScience, 2022 Summary: To investigate biological mechanisms underlying social behaviors and their deficits, social communication via ultrasonic vocalizations (USVs) in mice has received considerable attention as a powerful experimental model.
Jumpei Matsumoto +7 more
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Rapid fluorescent vital imaging of olfactory epithelium
iScience, 2022 Summary: Olfactory epithelium (OE) undergoes degeneration in disorders such as age-related and post-viral olfactory dysfunction. However, methods for real-time in vivo detection of OE and assessment of total extent within the nasal cavity are currently ...
Hironobu Nishijima +6 more
doaj +1 more source
The Rigor and Transparency Index Quality Metric for Assessing Biological and Medical Science Methods
iScience, 2020 Summary: The reproducibility crisis is a multifaceted problem involving ingrained practices within the scientific community. Fortunately, some causes are addressed by the author's adherence to rigor and reproducibility criteria, implemented via ...
Joe Menke +4 more
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Biological nanopores for single-molecule sensing
iScience, 2022 Summary: Evolution has found countless ways to transport material across cells and cellular compartments separated by membranes. Protein assemblies are the cornerstone for the formation of channels and pores that enable this regulated passage of ...
Simon Finn Mayer +2 more
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iScience, 2023 Summary: Unpublished data and unused samples are common byproducts of research activity, but little is known about the scope and economic impact of their disuse.
Emma C. Bowers +3 more
doaj +1 more source
Precision vibratome for high-speed ultrathin biotissue cutting and organ-wide imaging
iScience, 2021 Summary: Cutting tissues into ultrathin slices is highly desired in sectioning-based organ-wide imaging. However, it is difficult to perform tissue cutting at a high speed with excellent quality.
Yafeng Li +8 more
doaj +1 more source