Results 1 to 10 of about 1,326,546 (323)
Saporin as a Commercial Reagent: Its Uses and Unexpected Impacts in the Biological Sciences—Tools from the Plant Kingdom [PDF]
Toxins, 2022 Saporin is a ribosome-inactivating protein that can cause inhibition of protein synthesis and causes cell death when delivered inside a cell. Development of commercial Saporin results in a technology termed ‘molecular surgery’, with Saporin as the ...
Leonardo R. Ancheta +4 more
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Data Management Plan for a Biotechnology and Biological Sciences Research Council (BBSRC) Tools and Resources Development Fund (TRDF) Grant [PDF]
Research Ideas and Outcomes, 2017 Laurent Gatto
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Systems biology in animal sciences [PDF]
Animal, 2011 Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract ...
H. Woelders +4 more
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iScience, 2022 Summary: Aortic endothelial cell dysfunction is an early trigger of atherosclerosis, the major cause of the cardiovascular disease (CVD). Nanomedicines targeting vascular endothelium and lesions hold great promise as therapeutic solutions to vascular ...
Yuxiang Zhou +9 more
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iScience, 2023 Summary: Millions of single nucleotide variants (SNVs) exist in the human genome; however, it remains challenging to identify functional SNVs associated with diseases.
Mingyi Yang +3 more
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Integrative processing of untargeted metabolomic and lipidomic data using MultiABLER
iScience, 2023 Summary: Mass spectrometry (MS)-based untargeted metabolomic and lipidomic approaches are being used increasingly in biomedical research. The adoption and integration of these data are critical to the overall multi-omic toolkit.
Ian C.H. Lee +4 more
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Physical and chemical mechanisms of tissue optical clearing
iScience, 2021 Summary: Advanced optical methods combined with various probes pave the way toward molecular imaging within living cells. However, major challenges are associated with the need to enhance the imaging resolution even further to the subcellular level for ...
Tingting Yu +3 more
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iScience, 2023 Summary: Despite its profound impact on biology, high-resolution in vivo microscopy largely remains low throughput because current immobilization techniques require substantial manual effort.
Yao L. Wang +4 more
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The role of antigen expression in shaping the repertoire of HLA presented ligands
iScience, 2022 Summary: Human leukocyte antigen (HLA) presentation of peptides is a prerequisite of T cell immune activation. The understanding of the rules defining this event has large implications for our knowledge of basic immunology and for the rational design of ...
Heli M. Garcia Alvarez +3 more
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iScience, 2022 Summary: Early detection of pathogenic bacteria is needed for rapid diagnostics allowing adequate and timely treatment of infections. In this study, we show that secondary electrospray ionization–high resolution mass spectrometry (SESI-HRMS) can be used ...
Alejandro Gómez-Mejia +7 more
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