Results 101 to 110 of about 1,326,546 (323)
Reproducible computational biology experiments with SED-ML - The Simulation Experiment Description Markup Language [PDF]
, 2011 Background: The increasing use of computational simulation experiments to inform modern biological research creates new challenges to annotate, archive, share and reproduce such experiments.
Adams, Richard +10 more
core +6 more sources
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
, 2019 For decades, the use of HPC systems was limited to those in the physical sciences who had mastered their domain in conjunction with a deep understanding of HPC architectures and algorithms.
Arcand, William +17 more
core +1 more source
Complex Systems Science: Dreams of Universality, Reality of Interdisciplinarity [PDF]
, 2012 Using a large database (~ 215 000 records) of relevant articles, we empirically study the "complex systems" field and its claims to find universal principles applying to systems in general. The study of references shared by the papers allows us to obtain
Bastian M. +9 more
core +4 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
COMPARISON OF BIG DATA ANALYTICS TOOLS: A BIOINFORMATICS CASE STUDY
FUUAST Journal of Biology, 2021 Due to the exponential growth of genomic sequence in the field of biological science, it becomes the immense challenge for biomedical practitioners and researchers to access and analyze it.
MUHAMMAD SHAHZAD, KAMRAN AHSAN
doaj
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Large-scale event extraction from literature with multi-level gene normalization [PDF]
, 2013 Text mining for the life sciences aims to aid database curation, knowledge summarization and information retrieval through the automated processing of biomedical texts.
Ananiadou, Sophia +10 more
core +3 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
ARCAD, a structuring node in the French plant genetic resource conservation system [PDF]
, 2013 Agriculture in France has a primal role in economy and in rural organization throughout a a very broad climatic and geographic distribution (mainland and overseas territories).
Glaszmann, Jean-Christophe +2 more
core