Results 101 to 110 of about 1,815,049 (345)

Minimum Information About a Simulation Experiment (MIASE) [PDF]

, 2011
Reproducibility of experiments is a basic requirement for science. Minimum Information (MI) guidelines have proved a helpful means of enabling reuse of existing work in modern biology. The Minimum Information Required in the Annotation of Models (MIRIAM)
Hucka, Michael, Waltemath, Dagmar
core   +3 more sources

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Natural product sciences: an integrative approach to the innovations of plant natural products

Science China Life Sciences, 2020
The study on plant natural products not only helps us understand that their structural diversity is the inevitable result of plant species diversity, but also helps us understand certain rules and unity of the inevitable connection between the two.
Yuemao Shen, X. Hao
semanticscholar   +1 more source

Open Science principles for accelerating trait-based science across the Tree of Life. [PDF]

, 2020
Synthesizing trait observations and knowledge across the Tree of Life remains a grand challenge for biodiversity science. Species traits are widely used in ecological and evolutionary science, and new data and methods have proliferated rapidly.
Adams, Vanessa M, Alroy, John, Andrew, Samuel C, Ankenbrand, Markus J, Balk, Meghan A, Bland, Lucie M, Boyle, Brad L, Bravo-Avila, Catherine H, Brennan, Ian, Carthey, Alexandra JR, Catullo, Renee, Cavazos, Brittany R, Chown, Steven L, Conde, Dalia A, Enquist, Brian J, Fadrique, Belen, Falster, Daniel S, Feng, Xiao, Gallagher, Rachael V, Gibb, Heloise, Halbritter, Aud H, Hammock, Jennifer, Hogan, J Aaron, Holewa, Hamish, Hope, Michael, Iversen, Colleen M, Jochum, Malte, Kattge, Jens, Kearney, Michael, Keller, Alexander, Mabee, Paula, Madin, Joshua S, Maitner, Brian S, Manning, Peter, McCormack, Luke, Michaletz, Sean T, Park, Daniel S, Pearse, William D, Penone, Caterina, Perez, Timothy M, Pineda-Munoz, Silvia, Poelen, Jorrit H, Ray, Courtenay A, Rossetto, Maurizio, Salguero-Gómez, Roberto, Sauquet, Hervé, Schneider, Florian D, Sparrow, Benjamin, Spasojevic, Marko J, Telford, Richard J, Tobias, Joseph A, Vandvik, Vigdis, Violle, Cyrille, Walls, Ramona, Weiss, Katherine CB, Westoby, Mark, Wright, Ian J   +56 more
core   +4 more sources

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Impact of Iron Deficiency on the Growth and Bioelectrical Profile of Different Gut Bacteria

MicrobiologyOpen
Scope: Iron deficiency (ID) is the most common nutritional deficiency worldwide, impacting gut bacteria's metabolism and cellular biochemistry, but its effects on the microbiota‐gut‐brain axis (MGB) are poorly understood.
Elisa Quarta, Marwane Bourqqia‐Ramzi, David Muñoz‐Rodriguez, María Teresa García‐Esteban, Antonio Murciano‐Cespedosa, Álvaro Mateos González, Francisco José Conejero‐Meca, Juan Lombardo‐Hernandez, Jesús Mansilla‐Guardiola, Simona Baroni, Simonetta Geninatti Crich, Stefano Geuna, Luca Munaron, Deborah Chiabrando, Celia Herrera‐Rincon   +14 more
doaj   +1 more source

Community-based Linking of Biological Network Resources: Databases, Formats and Tools

Journal of Integrative Bioinformatics, 2007
The analysis of biological networks is increasingly important in the life sciences and in particular in systems biology. Computer-based analysis tools are exploited for the investigation of these networks.
Telgkamp Michael, Koschützki Dirk, Schwöbbermeyer Henning, Schreiber Falk   +3 more
doaj   +1 more source

Integrative biological simulation praxis: Considerations from physics, philosophy, and data/model curation practices [PDF]

, 2017
Integrative biological simulations have a varied and controversial history in the biological sciences. From computational models of organelles, cells, and simple organisms, to physiological models of tissues, organ systems, and ecosystems, a diverse ...
Faundez, Victor, Sarma, Gopal P.
core   +2 more sources

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

mCerulean3-Based Cameleon Sensor to Explore Mitochondrial Ca2+ Dynamics In Vivo

iScience, 2019
Summary: Genetically Encoded Ca2+ Indicators (GECIs) are extensively used to study organelle Ca2+ homeostasis, although some available probes are still plagued by a number of problems, e.g., low fluorescence intensity, partial mistargeting, and pH ...
Elisa Greotti, Ilaria Fortunati, Diana Pendin, Camilla Ferrante, Luisa Galla, Lorena Zentilin, Mauro Giacca, Nina Kaludercic, Moises Di Sante, Letizia Mariotti, Annamaria Lia, Marta Gómez-Gonzalo, Michele Sessolo, Giorgio Carmignoto, Renato Bozio, Tullio Pozzan   +15 more
doaj   +1 more source