Results 31 to 40 of about 1,815,049 (345)
iScience, 2023 Summary: Millions of single nucleotide variants (SNVs) exist in the human genome; however, it remains challenging to identify functional SNVs associated with diseases.
Mingyi Yang +3 more
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Integrative processing of untargeted metabolomic and lipidomic data using MultiABLER
iScience, 2023 Summary: Mass spectrometry (MS)-based untargeted metabolomic and lipidomic approaches are being used increasingly in biomedical research. The adoption and integration of these data are critical to the overall multi-omic toolkit.
Ian C.H. Lee +4 more
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Physical and chemical mechanisms of tissue optical clearing
iScience, 2021 Summary: Advanced optical methods combined with various probes pave the way toward molecular imaging within living cells. However, major challenges are associated with the need to enhance the imaging resolution even further to the subcellular level for ...
Tingting Yu +3 more
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iScience, 2023 Summary: Despite its profound impact on biology, high-resolution in vivo microscopy largely remains low throughput because current immobilization techniques require substantial manual effort.
Yao L. Wang +4 more
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The role of antigen expression in shaping the repertoire of HLA presented ligands
iScience, 2022 Summary: Human leukocyte antigen (HLA) presentation of peptides is a prerequisite of T cell immune activation. The understanding of the rules defining this event has large implications for our knowledge of basic immunology and for the rational design of ...
Heli M. Garcia Alvarez +3 more
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iScience, 2021 Summary: The mechanical properties of the extracellular matrix strongly influence tumor progression and invasion. Yes-associated protein (YAP) has been shown to be a key regulator of this process translating mechanical cues from the extracellular matrix ...
Bernhard Illes +6 more
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iScience, 2022 Summary: Early detection of pathogenic bacteria is needed for rapid diagnostics allowing adequate and timely treatment of infections. In this study, we show that secondary electrospray ionization–high resolution mass spectrometry (SESI-HRMS) can be used ...
Alejandro Gómez-Mejia +7 more
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Polyvalent guide RNAs for CRISPR antivirals
iScience, 2022 Summary: CRISPR effector Cas13 recognizes and degrades RNA molecules that are complementary to its guide RNA (gRNA) and possesses potential as an antiviral biotechnology because it can degrade viral mRNA and RNA genomes.
Rammyani Bagchi +6 more
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iScience, 2023 Summary: Functional explication of genes is of great scientific value. However, conventional methods have challenges for those genes that may affect biological processes but are not annotated in public databases.
Ying Wang +13 more
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Current Bioinformatics Tools to Optimize CRISPR/Cas9 Experiments to Reduce Off-Target Effects
International Journal of Molecular Sciences, 2023 The CRISPR-Cas system has evolved into a cutting-edge technology that has transformed the field of biological sciences through precise genetic manipulation.
Muhammad Naeem, Omer S. Alkhnbashi
semanticscholar +1 more source