Results 61 to 70 of about 1,815,049 (345)

Genomic Transformation of the Picoeukaryote Ostreococcus tauri [PDF]

, 2012
Common problems hindering rapid progress in Plant Sciences include cellular, tissue and whole organism complexity, and notably the high level of genomic redundancy affecting simple genetics in higher plants. The novel model organism Ostreococcus tauri is
Bouget, François-Yves, Kis, Katalin, Knox, Kirsten, Millar, Andrew J, van Ooijen, Gerben   +4 more
core   +1 more source

A robust vessel-labeling pipeline with high tissue clearing compatibility for 3D mapping of vascular networks

iScience
Summary: The combination of vessel-labeling, tissue-clearing, and light-sheet imaging techniques provides a potent tool for accurately mapping vascular networks, enabling the assessment of vascular remodeling in vascular-related disorders.
Yating Deng, Jingtan Zhu, Xiaomei Liu, Junyao Dai, Tingting Yu, Dan Zhu   +5 more
doaj   +1 more source

Tools for Sequence-Based miRNA Target Prediction: What to Choose?

International Journal of Molecular Sciences, 2016
MicroRNAs (miRNAs) are defined as small non-coding RNAs ~22 nt in length. They regulate gene expression at a post-transcriptional level through complementary base pairing with the target mRNA, leading to mRNA degradation and therefore blocking ...
A. Riffo-Campos, I. Riquelme, Priscilla Brebi-Mieville   +2 more
semanticscholar   +1 more source

Simulation-based model selection for dynamical systems in systems and population biology [PDF]

, 2010
Computer simulations have become an important tool across the biomedical sciences and beyond. For many important problems several different models or hypotheses exist and choosing which one best describes reality or observed data is not straightforward ...
Addy, Arbouzova, Beaumont, Blum, Burnham, Chen, Clancy, Darnell, Del Moral, Eigen, Excoffier, Gelman, Gillespie, Grelaud, Gutenkunst, Horvath, Jeffreys, Kass, Kim, Kirk, Klingmüller, Köster, Longini, Marjoram, May, Michael P. H. Stumpf, Möller, Müller, O'Neill, Prusiner, Ratmann, Ratmann, Secrier, Sisson, Swameye, Timmer, Tina Toni, Toni, Vyshemirsky, Wei, Wilkinson, Zi   +41 more
core   +3 more sources

Label-free 3D-CLEM Using Endogenous Tissue Landmarks

iScience, 2018
Summary: Emerging 3D correlative light and electron microscopy approaches enable studying neuronal structure-function relations at unprecedented depth and precision.
Manja Luckner, Steffen Burgold, Severin Filser, Maximilian Scheungrab, Yilmaz Niyaz, Eric Hummel, Gerhard Wanner, Jochen Herms   +7 more
doaj   +1 more source

Single-molecule fluorescence microscopy review : shedding new light on old problems [PDF]

, 2017
Fluorescence microscopy is an invaluable tool in the biosciences, a genuine workhorse technique offering exceptional contrast in conjunction with high specificity of labelling with relatively minimal perturbation to biological samples compared with many ...
Leake, Mark Christian, Shashkova, Sviatlana   +1 more
core   +1 more source

Interlaboratory consistency of SDC2 promoter methylation detection in colorectal cancer using the post-optimized materials

iScience
Summary: Fecal DNA-based Syndecan 2 (SDC2) methylation detection is a promising non-invasive strategy for early colorectal cancer (CRC) screening. In China, commercial assays for SDC2 methylation detection vary in sensitivity and specificity, yet there ...
Lijing Zhang, Duo Wang, Ziqiang Li, Guigao Lin, Jinming Li, Rui Zhang   +5 more
doaj   +1 more source

The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences

iScience, 2019
Lymphatic vessels mediate fluid flows that affect antigen distribution and delivery, lymph node stromal remodeling, and cell-cell interactions, to thus regulate immune activation.
Meghan J. O'Melia, Amanda W. Lund, Susan N. Thomas   +2 more
doaj   +1 more source

Strategies for structure elucidation of small molecules based on LC–MS/MS data from complex biological samples

Computational and Structural Biotechnology Journal, 2022
LC–MS/MS is a major analytical platform for metabolomics, which has become a recent hotspot in the research fields of life and environmental sciences. By contrast, structure elucidation of small molecules based on LC–MS/MS data remains a major challenge ...
Zhitao Tian, Fangzhou Liu, Dongqin Li, Alisdair R. Fernie, Wei Chen   +4 more
doaj   +1 more source

Why Biology is Beyond Physical Sciences? [PDF]

, 2016
In the framework of materialism, the major attention is to find general organizational laws stimulated by physical sciences, ignoring the uniqueness of Life.
Muni, Bhakti Vijnana, Shanta, Bhakti Niskama   +1 more
core   +1 more source