Results 81 to 90 of about 741,715 (194)

Biologics developability data analysis using hierarchical clustering accelerates candidate lead selection, optimization, and preformulation screening

mAbs
Identification of an optimal single protein sequence at the discovery stage for preclinical and clinical development is critical to the rapid development and overall success of a biologic drug.
Kevin James Metcalf, Galen Wo, Jan Paulo Zaragoza, Fahimeh Raoufi, Jeanne Baker, Daoyang Chen, Mehabaw Derebe, Jason Hogan, Amy Hsu, Esther Kofman, David Leigh, Mandy Li, Dan Malashock, Cate Mann, Soha Motlagh, Jihea Park, Karthik Sathiyamoorthy, Madhura Shidhore, Yinyan Tang, Kevin Teng, Katharine Williams, Andrew Waight, Sultan Yilmaz, Fan Zhang, Huimin Zhong, Laurence Fayadat-Dilman, Marc Bailly   +26 more
doaj   +1 more source

Pathways Across the Valley of Death: Novel Intellectual Property Strategies for Accelerated Drug Discovery [PDF]

, 2008
Drug discovery is stagnating. Government agencies, industry analysts, and industry scientists have all noted that, despite significant increases in pharmaceutical R&D funding, the production of fundamentally new drugs - particularly drugs that work on ...
Crossman, Colin, Rai, Arti K., Reichman, Jerome H., Uhlir, Paul F.   +3 more
core   +1 more source

Psoriasis Vulgaris Successfully Treated with Goeckerman Treatment at Home: A Patient and Physician's Experience. [PDF]

, 2020
Goeckerman therapy is a highly effective treatment regimen for moderate-to-severe psoriasis. It involves regular exposure to ultraviolet B radiation and the application of crude coal tar.
Bhutani, Tina, Liao, Wilson, Myers, Bridget, Reddy, Vidhatha, Thibodeaux, Quinn, Thomas, Shawn   +5 more
core  

Plant-Life on Land, considered in Some of its Biological Aspects [PDF]

, 1911
F. O. Bower
openalex   +1 more source

DB-1314, a novel DLL3-targeting ADC with DNA topoisomerase I inhibitor, exhibits promising safety profile and therapeutic efficacy in preclinical small cell lung cancer models

Journal of Translational Medicine
Background Delta-like ligand 3 (DLL3) is highly expressed on the cell surface of small cell lung cancer (SCLC), one of the most lethal malignancies, but minimally or not in normal tissues, making it an attractive target for SCLC.
Shengchao Lin, Yu Zhang, Jun Yao, Junjie Yang, Yang Qiu, Zhongyuan Zhu, Haiqing Hua   +6 more
doaj   +1 more source

Biological Assay of Insecticide Residues [PDF]

, 1959
Sumio Nagasawa
openalex   +1 more source

DB-1310, an ADC comprised of a novel anti-HER3 antibody conjugated to a DNA topoisomerase I inhibitor, is highly effective for the treatment of HER3-positive solid tumors

Journal of Translational Medicine
Background HER3 (ErbB3), a member of the human epidermal growth factor receptor family, is frequently overexpressed in various cancers. Multiple HER3-targeting antibodies and antibody–drug conjugates (ADCs) were developed for the solid tumor treatment ...
Xi Li, Jun Yao, Chen Qu, Lan Luo, Bing Li, Yu Zhang, Zhongyuan Zhu, Yang Qiu, Haiqing Hua   +8 more
doaj   +1 more source

Biological Notes [PDF]

, 1877

openalex   +1 more source

The Promising Viral Threat to Bacterial Resistance: The Uncertain Patentability of Phage Therapeutics and the Necessity of Alternative Incentives [PDF]

, 2014
Bacteriophages, or “phages,” are a category of highly adept and adaptable viruses that can infect and kill bacteria. With concerns over the burgeoning antibiotic-resistance crisis looming in recent years, scientists and policymakers have expressed a ...
Todd, Kelly
core   +1 more source

1339 Systemically administered onco-selective mRNA LNP achieves tumor regression and improves overall survival, as monotherapy

Journal for ImmunoTherapy of Cancer, 2023
Manfred Kraus, Aniela Jakubowski, Yulia Rybakova, Nicole Lessard, Rudy Christmas, Tom Addison, Leona Lee, Jieni Xu, Mark Krimmer, Cafer Ozdemir, Burak Yilmaz, Yusuf Erkul, Isaak Mueller   +12 more
doaj   +1 more source