Results 81 to 90 of about 774,999 (361)

Efficient Nonviral Transfection of Human Bone Marrow Mesenchymal Stromal Cells Shown Using Placental Growth Factor Overexpression

Stem Cells International, 2018
Background. Human mesenchymal stromal/stem cells (hMSCs) hold great therapeutic potential due to their immunomodulatory and tissue regenerative properties.
Winston Y. Cheung, Owen Hovey, Jonathan M. Gobin, Gauri Muradia, Jelica Mehic, Carole Westwood, Jessie R. Lavoie   +6 more
doaj   +1 more source

Preclinical Characterization of a Novel Monoclonal Antibody NEO-201 for the Treatment of Human Carcinomas

Frontiers in Immunology, 2018
NEO-201 is a novel humanized IgG1 monoclonal antibody that was derived from an immunogenic preparation of tumor-associated antigens from pooled allogeneic colon tumor tissue extracts.
Massimo Fantini, Justin M. David, Olga Saric, Alexander Dubeykovskiy, Yongzhi Cui, Sharon A. Mavroukakis, Andrew Bristol, Christina M. Annunziata, Kwong Y. Tsang, Philip M. Arlen   +9 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

A combined clinical and biological risk classification improves prediction of outcome in hepatoblastoma patients [PDF]

, 2020
Stefano Cairo, Carolina Armengol, Rudolf Maibach, Beate Häberle, Kristina Becker, Juan Carrillo-Reixach, Catherine Guettier, Christian Vokuhl, Irene Schmid, Marie‐Annick Buendia, Sophie Branchereau, Dietrich von Schweinitz, Roland Kappler   +12 more
openalex   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring. [PDF]

, 2019
The new and rapid advancement in the complexity of biologics drug discovery has been driven by a deeper understanding of biological systems combined with innovative new therapeutic modalities, paving the way to breakthrough therapies for previously ...
Chen, Ching, Chen, Irwin, Chong, Su, Hamburger, Agi, Jess, Philip, Jorgolli, Marsela, Le, Kim, Lin, Fen-Fen, Miranda, Les P, Mock, Marissa, Munro, Trent, Nevill, Tanner, Stevens, Jennitte, Tagari, Philip, Tan, Christopher, Winters, Aaron, Wu, Ming, Xu, Han   +17 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

The Role of Biologics Agent in the Treatment of Inflammatory Bowel Disease [PDF]

, 2017
Inflammatory bowel disease (IBD), with major manifestations as Crohn's disease (CD) and ulcerative colitis (UC), is a chronic intestinal inflammatory disorder with an unknown etiology which pathogensis involving multifactorial immune disorder ...
Guno, T. H. (Tri), Simadibrata, M. (Marcellus)   +1 more
core   +2 more sources

Biologicals [PDF]

International Journal of Rheumatology, 2012
de Carvalho, Jozélio Freire, Appenzeller, Simone, Shoenfeld, Yehuda   +2 more
openaire   +2 more sources

Sea Buckthorn (Hippophae rhamnoides) Waste Biomass after Harvesting as a Source of Valuable Biologically Active Compounds with Nutraceutical and Antibacterial Potential [PDF]

, 2022
Sarmīte Janceva, Anna Andersone, Līga Lauberte, Oskars Bikovens, Vizma Nikolajeva, Lilija Jashina, Natālija Zaharova, Галина Телышева, Māris Seņkovs, Gints Rieksts, Anna Ramata‐Stunda, Jeļena Krasiļņikova   +11 more
openalex   +1 more source