Results 81 to 90 of about 1,388,626 (353)

Negative Energy: Why Interdisciplinary Physics Requires Multiple Ontologies

, 2013
Much recent work in physics education research has focused on ontological metaphors for energy, particularly the substance ontology and its pedagogical affordances.
Dreyfus, Benjamin W., Geller, Benjamin D., Gouvea, Julia, Redish, Edward F., Sawtelle, Vashti, Turpen, Chandra   +5 more
core   +1 more source

Vacuolar transport and function of Saccharomyces cerevisiae sterol ester hydrolase Tgl1

FEBS Letters, EarlyView.
Tgl1, one of yeast sterol ester hydrolases, had been found on the lipid droplets where sterol esters are mainly stored. This study revealed that Tgl1 is transported into the vacuole depending on the ESCRT‐I–III complex, and that it exhibits intra‐vacuolar sterol ester hydrolase activity.
Takumi Nakatsuji, Kosuke Shiraishi, Chuqian Wang, Hiroya Yurimoto, Yasuyoshi Sakai, Masahide Oku   +5 more
wiley   +1 more source

Molecular storytelling: a conceptual framework for teaching and learning with molecular case studies

Frontiers in Education
Molecular case studies (MCSs) provide educational opportunities to explore biomolecular structure and function using data from public bioinformatics resources.
Caleb M. Trujillo, Shuchismita Dutta, Shuchismita Dutta, Shuchismita Dutta   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Evaluating Universal Design for Learning and Active Learning Strategies in Biology Open Educational Resources (OERs)

Teaching & Learning Inquiry: The ISSOTL Journal
With the onset of COVID-19, colleges and universities moved to emergency remote teaching, and instructors immediately adjusted their curricula. Many instructors adapted or developed new online lessons that they subsequently published as Open Educational
Krista Wojdak, Michelle K. Smith, Hayley Orndorf, Marie Louise Ramirez   +3 more
doaj   +1 more source

The Crisis in Biology Education

The American Biology Teacher, 1982
Robert E. Yager is professor of science education and director of the Science Education Center at the University of Iowa, Iowa City 52242. He holds a B.A. in biology from University of Northern Iowa, and an M.S. and a Ph.D. in physiology from the University of Iowa. He has directed 100 NSF institutes and special projects, authored 200 research reports,
openaire   +1 more source

Understanding the Transition between High School and College Mathematics and Science [PDF]

, 2010
Mathematics and science education is gaining increasing recognition as key for the well-being of individuals and society. Accordingly, the transition from high school to college is particularly important to ensure that students are prepared for college ...
Basile, C., Culpepper, S. A., Ferguson, C. A., Lanning, J. A., Perkins, M. A.   +4 more
core   +1 more source

Contexts for questioning: Two zones of teaching and learning in undergraduate science [PDF]

, 2012
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ Springer Science+Business Media B.V.
da Silva Lopes, B, Moreira, A, Pedrosa-de-Jesus, H, Watts, DM   +3 more
core   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source