Results 21 to 30 of about 2,458,031 (313)
Multiplexed protein profiling reveals spatial subcellular signaling networks
iScience, 2022 Summary: Protein-protein interaction networks are altered in multi-gene dysregulations in many disorders. Image-based protein multiplexing sheds light on signaling pathways to dissect cell-to-cell heterogeneity, previously masked by the bulk assays ...
Shuangyi Cai +7 more
doaj +1 more source
iScience, 2022 Summary: In vivo quantitative assessment of structural and functional biomarkers is essential for characterizing the pathophysiology of congenital disorders.
Tanveer Teranikar +9 more
doaj +1 more source
Combining Experimental Data and Computational Methods for the Non-Computer Specialist
Molecules, 2020 Experimental methods are indispensable for the study of the function of biological macromolecules, not just as static structures, but as dynamic systems that change conformation, bind partners, perform reactions, and respond to different stimulus ...
Reinier Cárdenas +2 more
doaj +1 more source
Direct capture and sequencing reveal ultra-short single-stranded DNA in biofluids
iScience, 2022 Summary: Cell-free DNA (cfDNA) has become the predominant analyte of liquid biopsy; however, recent studies suggest the presence of subnucleosomal-sized DNA fragments in circulation that are likely single-stranded.
Lauren Y. Cheng +4 more
doaj +1 more source
Spatial accuracy evaluation of magnetic source imaging methods on OPM-based MEG
iScience, 2022 Summary: The emergence of the optically pumped magnetometer (OPM)-based magnetoencephalography (MEG) has led to new developments in MEG technology.
Nan An +11 more
doaj +1 more source
PCR-based profiling of transcription factor activity in vivo by a virus-based reporter battery
iScience, 2022 Summary: Understanding the molecular mechanisms of gene regulation is pivotal for understanding how cells establish and modify their identities and functions.
Hitomi Abe, Kentaro Abe
doaj +1 more source
ChlamyCyc - a comprehensive database and web-portal centered on _Chlamydomonas reinhardtii_ [PDF]
, 2009 *Background* - The unicellular green alga _Chlamydomonas reinhardtii_ is an important eukaryotic model organism for the study of photosynthesis and growth, as well as flagella development and other cellular processes.
Dirk Walther +3 more
core +2 more sources
Specificity and efficiency of tamoxifen-mediated Cre induction is equivalent regardless of age
iScience, 2023 Summary: Temporally controlling Cre recombination through tamoxifen (Tam) induction has many advantages for biomedical research. Most studies report early post-natal/juvenile (12 m.o.).
Collyn M. Kellogg +10 more
doaj +1 more source
A Framework for Directional and Higher-Order Reconstruction in Photoacoustic Tomography [PDF]
, 2017 Photoacoustic tomography is a hybrid imaging technique that combines high optical tissue contrast with high ultrasound resolution. Direct reconstruction methods such as filtered backprojection, time reversal and least squares suffer from curved line ...
Boink, Yoeri E. +5 more
core +6 more sources
iScience, 2022 Summary: Microfluidic dielectrophoresis (DEP) technology has been applied to many devices to perform label-free target cell separation. Cells separated by these devices are used in laboratories, mainly for medical research.
Kyoichi Oshiro +8 more
doaj +1 more source