Results 21 to 30 of about 2,476,127 (290)

Dysregulation of ribosome-related genes in ankylosing spondylitis: a systems biology approach and experimental method [PDF]

BMC Musculoskeletal Disorders, 2021
Abstract Background Ankylosing spondylitis (AS) is an autoimmune rheumatic disease. Few candidate gene associations have been reported for AS and the current understanding of its pathogenesis remains still poor. Thus, the exact mechanism of AS is needed to urgently be disclosed.
Arezou Lari, Hamid Gholami Pourbadie, Ali Sharifi-Zarchi, Maryam Akhtari, Leila Nejatbakhsh Samimi, Ahmadreza Jamshidi, Mahdi Mahmoudi   +6 more
openaire   +3 more sources

Immortalized human choroid plexus endothelial cells enable an advanced endothelial-epithelial two-cell type in vitro model of the choroid plexus

iScience, 2022
Summary: The choroid plexus (CP) is a highly vascularized structure containing endothelial and epithelial cells located in the ventricular system of the central nervous system (CNS).
Walter Muranyi, Christian Schwerk, Rosanna Herold, Carolin Stump-Guthier, Marko Lampe, Petra Fallier-Becker, Christel Weiß, Carsten Sticht, Hiroshi Ishikawa, Horst Schroten   +9 more
doaj   +1 more source

The proteomic profile of the human myotendinous junction

iScience, 2022
Summary: Proteomics analysis of skeletal muscle has recently progressed from whole muscle tissue to single myofibers. Here, we further focus on a specific myofiber domain crucial for force transmission from muscle to tendon, the myotendinous junction ...
Anders Karlsen, Alba Gonzalez-Franquesa, Jens R. Jakobsen, Michael R. Krogsgaard, Manuel Koch, Michael Kjaer, Stefano Schiaffino, Abigail L. Mackey, Atul S. Deshmukh   +8 more
doaj   +1 more source

Three live-imaging techniques for comprehensively understanding the initial trigger for insulin-responsive intracellular GLUT4 trafficking

iScience, 2022
Summary: Quantitative features of GLUT4 glucose transporter’s behavior deep inside cells remain largely unknown. Our previous analyses with live-cell imaging of intracellular GLUT4 trafficking demonstrated two crucial early events responsible for ...
Hiroyasu Hatakeyama, Ko Kobayashi, Makoto Kanzaki   +2 more
doaj   +1 more source

Editorial: Exploration of the role of heme proteins in biology with experimental and computational methods

Frontiers in Chemistry
Dragan M. Popović, Sergey A. Siletsky, Chunmao He, M. R. Gunner   +3 more
doaj   +3 more sources

Precision vibratome for high-speed ultrathin biotissue cutting and organ-wide imaging

iScience, 2021
Summary: Cutting tissues into ultrathin slices is highly desired in sectioning-based organ-wide imaging. However, it is difficult to perform tissue cutting at a high speed with excellent quality.
Yafeng Li, Zhangheng Ding, Lei Deng, Guoqing Fan, Qi Zhang, Hui Gong, Anan Li, Jing Yuan, Jianwei Chen   +8 more
doaj   +1 more source

Conformational effects on the Circular Dichroism of Human Carbonic Anhydrase II: a multilevel computational study [PDF]

, 2013
Circular Dichroism (CD) spectroscopy is a powerful method for investigating conformational changes in proteins and therefore has numerous applications in structural and molecular biology. Here a computational investigation of the CD spectrum of the Human
A Roy, B Hess, BM Bulheller, BM Bulheller, C Christov, C Christov, C Christov, C Christov, C Christov, C Christov, CD Andrew, Christo Z. Christov, D Robinson, D Robinson, DM Rogers, DM Rogers, Gary W. Black, HJC Berendsen, J Hudecova, K Hakansson, Kia Balali-Mood, M Karplus, M Karplus, M Li, ME Casida, N Berova, NA Besley, P-O Freskgaard, PM Bayley, R Rodriguez, RW Woody, RW Woody, S Lindskog, SA Adcock, SM Kelly, T Karabencheva, T Karabencheva, Tatyana G. Karabencheva-Christova, U Essmann, Uno Carlsson, Vladimir N. Uversky, W Humphrey, WJ Goux   +42 more
core   +8 more sources

Multiplexed protein profiling reveals spatial subcellular signaling networks

iScience, 2022
Summary: Protein-protein interaction networks are altered in multi-gene dysregulations in many disorders. Image-based protein multiplexing sheds light on signaling pathways to dissect cell-to-cell heterogeneity, previously masked by the bulk assays ...
Shuangyi Cai, Thomas Hu, Mythreye Venkatesan, Mayar Allam, Frank Schneider, Suresh S. Ramalingam, Shi-Yong Sun, Ahmet F. Coskun   +7 more
doaj   +1 more source

Scale space detector for analyzing spatiotemporal ventricular contractility and nuclear morphogenesis in zebrafish

iScience, 2022
Summary: In vivo quantitative assessment of structural and functional biomarkers is essential for characterizing the pathophysiology of congenital disorders.
Tanveer Teranikar, Cameron Villarreal, Nabid Salehin, Toluwani Ijaseun, Jessica Lim, Cynthia Dominguez, Vivian Nguyen, Hung Cao, Cheng–Jen Chuong, Juhyun Lee   +9 more
doaj   +1 more source

Direct capture and sequencing reveal ultra-short single-stranded DNA in biofluids

iScience, 2022
Summary: Cell-free DNA (cfDNA) has become the predominant analyte of liquid biopsy; however, recent studies suggest the presence of subnucleosomal-sized DNA fragments in circulation that are likely single-stranded.
Lauren Y. Cheng, Peng Dai, Lucia R. Wu, Abhijit A. Patel, David Yu Zhang   +4 more
doaj   +1 more source