Results 141 to 150 of about 113,231 (318)
Advanced Science, EarlyView.This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu +11 more
wiley +1 more source
Those that are lucky enough to have seen a bioluminescent beach say it is a fantastic spectacle, like few on Earth. The sparks of blue or green light that accompany the water in the winding breaking of the waves captivate young and old alike. I, unfortunately, have never seen it, although I have seen occasional sparks in the night water, and I have ...
openaire +2 more sources
Advanced Science, EarlyView.This study unveils a novel GAA (GCN5‐ADA2‐ACL) complex that forms nuclear condensates to boost local acetyl‐CoA, facilitating histone acetylation and gene transcription in rice meristems. The research underscores the role of ADA2's disordered region in complex condensation and ACL's role in acetyl‐CoA production.
Yaping Yue +11 more
wiley +1 more source
Advanced Science, EarlyView.Schematic illustration of the proposed model. Primary CAFs are isolated from fresh human GBM specimens according to established protocols. GLUL is essential for pro‐angiogenic capacity of CAFs through its impact on the PI3K/AKT pathway. GLUL enhances the pro‐angiogenic capacity of CAFs, driving aberrant tumor vasculature that fuels tumor growth ...
Qing Zhang +4 more
wiley +1 more source
Light Emission Requires Exposure to the Atmosphere in Ex Vivo Bioluminescence Imaging [PDF]
, 2006 Yusuke Inoue +5 more
openalex +1 more source
Advanced Science, EarlyView.Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang +14 more
wiley +1 more source
ATP measurement as method to monitor the quality of reprocessing flexible endoscopes
GMS German Medical Science, 2004 Insufficient performance of cleaning and disinfection of flexible endoscopes can pose an infection risk to patients. Actually quality of reprocessing is checked by performing microbiological cultures. Unfortunately, their results are not available on the
Hansen, Dorothea +5 more
doaj
SEASONAL VARIABILITY OF THE BIOLUMINESCENCE FIELD OFF THE COASTAL AREA OF THE CAUCASUS IN THE PERIOD OF 2018 [PDF]
, 2019 Александр Владимирович Мельник +1 more
openalex +1 more source
Magnetically‐Induced Suppression of Oxidative Stress Prevents Venous Thrombosis
Advanced Science, EarlyView.Venous thromboembolism (VTE) remains a leading cause of cardiovascular mortality. This study demonstrates that static magnetic fields (SMF) offer a novel non‐pharmacological intervention against VTE by mitigating endothelial oxidative stress. Mechanistically, SMF elevates intracellular Ca2+, boosts ATP production, and suppresses NOX4‐mediated ROS ...
Nana Zhang +12 more
wiley +1 more source
Monitoring Bip promoter activation during cancer cell growth by bioluminescence imaging at the single-cell level [PDF]
, 2016 Tomohisa Horibe +6 more
openalex +1 more source