Results 141 to 150 of about 64,944 (323)

Sustained activity of novel THIOMAB antibody-antibiotic conjugate against Staphylococcus aureus in a mouse model: Longitudinal pharmacodynamic assessment by bioluminescence imaging.

PLoS ONE, 2019
Staphylococcus aureus (S. aureus) infections are a leading cause of death by an infectious agent. Survival within host phagocytic cells is one mechanism by which S. aureus evades antibiotic treatment.
Chenguang Zhou, Hao Cai, Amos Baruch, Nicholas Lewin-Koh, Meng Yang, Fengxun Guo, Deming Xu, Rong Deng, Wouter Hazenbos, Amrita V Kamath   +9 more
doaj   +1 more source

Monitoring Bip promoter activation during cancer cell growth by bioluminescence imaging at the single-cell level [PDF]

, 2016
Tomohisa Horibe, Aya Torisawa, Ryohsuke Kurihara, Ryutaro Akiyoshi, Yoko Hatta‐Ohashi, Hirobumi Suzuki, Koji Kawakami   +6 more
openalex   +1 more source

KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression

Advanced Science, EarlyView.
Cholangiocarcinoma (CCA) driven by oncogenic KRAS depends on its continuous activation for tumor maintenance. Using a conditional KRAS model, the authors show that turning off KRAS triggers rapid tumor regression accompanied by immune cell infiltration and cytokine release. The findings uncover a KRAS–senescence–immune signaling axis and highlight KRAS
Youwei Qiao, Matthew F. Yee, Chaitanya N. Parikh, Boyang Ma, Yueying Cao, Yu‐Huan Shih, Joae Qiong Wu, Marcus Ruscetti, Shun‐Qing Liang, Wen Xue   +9 more
wiley   +1 more source

A dual-luciferase bioluminescence system for the assessment of cellular therapies

Molecular Therapy: Oncology
Bioluminescence imaging is a well-established platform for evaluating engineered cell therapies in preclinical studies. However, despite the discovery of new luciferases and substrates, optimal combinations to simultaneously monitor two cell populations ...
Alejandro G. Torres Chavez, Mary K. McKenna, Kishore Balasubramanian, Lisa Riffle, Nimit L. Patel, Joseph D. Kalen, Brad St. Croix, Ann M. Leen, Pradip Bajgain   +8 more
doaj   +1 more source

Improved light extraction in the bioluminescent lantern of a Photuris firefly (Lampyridae)

, 2013
A common problem of light sources emitting from an homogeneous high-refractive index medium into air is the loss of photons by total internal reflection. Bioluminescent organisms, as well as artificial devices, have to face this problem.
Bay, Annick, Cloetens, Peter, Suhonen, Heikki, Vigneron, Jean Pol   +3 more
core   +3 more sources

Comparing in vivo bioluminescence imaging and the Multi-Cruzi immunoassay platform to develop improved Chagas disease diagnostic procedures and biomarkers for monitoring parasitological cure

, 2022
Amanda Fortes Francisco, Ursula Saade, Shiromani Jayawardhana, Hans Pottel, Ivan Scandale, Eric Chatelain, Peter Liehl, John M. Kelly, Maan Zrein   +8 more
openalex   +2 more sources

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Giardia Colonizes and Encysts in High-Density Foci in the Murine Small Intestine. [PDF]

, 2017
Giardia lamblia is a highly prevalent yet understudied protistan parasite causing significant diarrheal disease worldwide. Hosts ingest Giardia cysts from contaminated sources.
Barash, NR, Dawson, SC, Gourguechon, S, McCarthy-Sinclair, B, McInally, SG, Nosala, C, Pham, JK   +6 more
core  

Comparison between bioluminescence imaging technique and CFU count for the study of oropharyngeal candidiasis in mice [PDF]

, 2015
Elena Gabrielli, Elena Roselletti, Eugenio Luciano, Samuele Sabbatini, Paolo Mosci, Eva Pericolini   +5 more
openalex   +1 more source

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science, EarlyView.
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
wiley   +1 more source