Results 251 to 260 of about 44,745 (290)

Bioorthogonal chemistry in bioluminescence imaging

Drug Discovery Today, 2018
Bioorthogonal chemistry has developed significant over the past few decades, to the particular benefit of molecular imaging. Bioluminescence imaging (BLI) along with other imaging modalities have significantly benefitted from this chemistry. Here, we review bioorthogonal reactions that have been used to signific antly broaden the application range of ...
Aurélien Godinat, Arkadiy A. Bazhin, Elena A. Goun   +2 more
openaire   +4 more sources

- Bioluminescence Imaging

, 2016
A, serial evaluation of transplanted graft survival by bioluminescence imaging in the allogeneic and syngeneic Tx groups; B, quantitative comparison of bioluminescence between the allogeneic and syngeneic Tx groups; C, teratoma formation in the syngeneic
Yasukazu Kanai (630292), Ai Kawamura (651809), Koichi Toda (651812), Jun Hatazawa (630297), Shigeru Miyagawa (310845), Akima Harada (3387104), Yoshiki Sawa (219191), Satsuki Fukushima (75828), Tadashi Watabe (630288), Takuji Kawamura (651807), Shohei Yoshida (517200), Noriyuki Kashiyama (651808)   +11 more
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Red-shifted luciferase–luciferin pairs for enhanced bioluminescence imaging [PDF]

Nature Methods, 2017
Red-shifted bioluminescence reporters are desirable for biological imaging. We describe the development of red-shifted luciferins based on synthetic coelenterazine analogs and corresponding mutants of NanoLuc that enable bright bioluminescence.
Hsien-Wei Yeh, Manuela Martins-Green, Hui-Wang Ai   +2 more
exaly   +2 more sources

Real-Time Bioluminescence Imaging of Nitroreductase in Mouse Model

Analytical Chemistry, 2016
Nitroreductase (NTR) is an endogenous reductase overexpressed in hypoxic tumors; however, its precise detection in living cells and animals remains a considerable challenge.
Ping Feng, Linghui Yang, Guo-Bo Li
exaly   +2 more sources

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Bioluminescent Imaging in Bone

2008
Monitoring gene expression in vitro and in vivo, is crucial when analyzing osteogenesis and developing effective bone gene therapy protocols. Until recently, molecular analytical tools were only able to detect protein expression either in vitro or in vivo.
Yoram, Zilberman, Yossi, Gafni, Gadi, Pelled, Zulma, Gazit, Dan, Gazit   +4 more
openaire   +2 more sources

Bioluminescence imaging in living organisms

Current Opinion in Biotechnology, 2005
Luciferase enzymes catalyze the emission of light from a substrate -- a phenomenon known as bioluminescence -- and have been employed as reporters of many biological functions. Luminescent reporters are much dimmer than fluorescent reporters, and therefore provide relatively modest spatial and temporal resolution. Yet, they are generally more sensitive
David K, Welsh, Steve A, Kay
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In Vivo Imaging of Bioluminescent Leptospires

2020
The study of pathological processes is often limited to in vitro or ex vivo assays, while understanding pathogenesis of an infectious disease requires in vivo analysis. The use of pathogens, genetically modified to express with luminescent enzymes, combined to charge-coupled device (CCD) cameras, constitutes a major technological advance for assessing ...
Vernel-Pauillac, Frédérique, Werts, Catherine   +1 more
openaire   +3 more sources

Bioluminescence imaging: looking beyond the light

Trends in Molecular Medicine, 2012
Bioluminescence imaging (BLI) enables in vivo imaging of molecular and cellular processes. It has gained in popularity over the past decade because of its easy translation from in vitro to in vivo experiments, its sensitivity, and its ease of use.
Keyaerts, Marleen, Caveliers, Vicky, Lahoutte, Tony   +2 more
openaire   +3 more sources

Cellular Bioluminescence Imaging

Cold Spring Harbor Protocols, 2012
Bioluminescence imaging of live cells has recently been recognized as an important alternative to fluorescence imaging. Fluorescent probes are much brighter than bioluminescent probes (luciferase enzymes) and, therefore, provide much better spatial and temporal resolution and much better contrast for delineating cell structure.
David K. Welsh, Takako Noguchi
openaire   +1 more source

Validation of Bioluminescent Imaging Techniques

2009
Bioluminescence imaging (BLI) is frequently cited for its ease of quantification. This fundamental strength of BLI has led to applications in cancer research, cell transplantation, and monitoring of infectious disease in which bioluminescence intensity is correlated with other metrics. However, bioluminescence measurements can be influenced by a number
John, Virostko, E Duco, Jansen
openaire   +2 more sources