Results 21 to 30 of about 64,944 (323)
In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice. [PDF]
, 2012 Xenograft mouse models represent helpful tools for preclinical studies on human tumors. For modeling the complexity of the human disease, primary tumor cells are by far superior to established cell lines.
Brentjens, Renier J. +12 more
core +8 more sources
Development of bioluminescent bioreporters for in vitro and in vivo tracking of Yersinia pestis. [PDF]
PLoS ONE, 2012 Yersinia pestis causes an acute infection known as the plague. Conventional techniques to enumerate Y. pestis can be labor intensive and do not lend themselves to high throughput assays.
Yanwen Sun +3 more
doaj +1 more source
Emerging tools for bioluminescence imaging
Current Opinion in Chemical Biology, 2021 Bioluminescence (BL) relies on the enzymatic reaction between luciferase, a substrate conventionally named luciferin, and various cofactors. BL imaging has become a widely used technique to interrogate gene expression and cell fate, both in small and large animal models of research.
Zambito, Giorgia +2 more
openaire +2 more sources
Multicomponent Bioluminescence Imaging with Naphthylamino Luciferins. [PDF]
Chembiochem, 2021 AbstractBioluminescent tools have been used for decades to image processes in complex tissues and preclinical models. However, few distinct probes are available to probe multicellular interactions. We and others are addressing this limitation by engineering new luciferases that can selectively process synthetic luciferin analogues.
Brennan CK +3 more
europepmc +5 more sources
Frontiers in Bioengineering and Biotechnology, 2019 Early detection of tumors is today a major challenge and requires sensitive imaging methodologies coupled with new efficient probes. In vivo optical bioluminescence imaging has been widely used in the field of preclinical oncology to visualize tumors and
Fabiane Sônego +8 more
doaj +1 more source
Impact of Anesthesia Protocols on In Vivo Bioluminescent Bacteria Imaging Results. [PDF]
PLoS ONE, 2015 Infectious murine models greatly benefit from optical imaging using bioluminescent bacteria to non-invasively and repeatedly follow in vivo bacterial infection.
Thomas Chuzel +11 more
doaj +1 more source
Bioluminescence imaging in bone tissue engineering [PDF]
, 2009 This thesis contains two parts. The first part is to study the effect of a signalling pathway of protein kinase C (PKC) on human mesenchymal stem cells (hMSCs) commitment to osteogenesis (chapter 1-2). We observed different PKC isozymes working differently for osteogenic differentiation.
Jun Liu
openalex +3 more sources
Automated quantification of bioluminescence images [PDF]
Nature Communications, 2018 AbstractWe developed a computer-aided analysis tool for quantitatively determining bioluminescent reporter distributions inside small animals. The core innovations are a body-fitting animal shuttle and a statistical mouse atlas, both of which are spatially aligned and scaled according to the animal’s weight, and hence provide data congruency across ...
Alexander D. Klose, Neal Paragas
openaire +3 more sources
Reversible low-light induced photoswitching of crowned spiropyran-DO3A complexed with gadolinium(III) ions. [PDF]
, 2012 Photoswitchable spiropyran has been conjugated to the crowned ring system DO3A, which improves its solubility in dipolar and polar media and stabilizes the merocyanine isomer. Adding the lanthanide ion gadolinium(III) to the macrocyclic ring system leads
Brueggemann, Chantal +6 more
core +4 more sources
Bioluminescence imaging: progress and applications [PDF]
Trends in Biotechnology, 2011 Application of bioluminescence imaging has increased tremendously in the past decade and has significantly contributed to core conceptual advances in biomedical research. This technology provides valuable means for monitoring of different biological processes in immunology, oncology, virology and neuroscience.
Christian E, Badr, Bakhos A, Tannous
openaire +2 more sources