Results 21 to 30 of about 6,926,142 (285)

In vivo bioluminescence imaging of granzyme B activity in tumor response to cancer immunotherapy. [PDF]

Cell Chem Biol, 2022
Summary Cancer immunotherapy has revolutionized the treatment of cancer, but only a small subset of patients is benefited from this new treatment regime.
Chen M, Zhou K, Dai SY, Tadepalli S, Balakrishnan PB, Xie J, Rami FEI, Dai T, Cui L, Idoyaga J, Rao J.   +10 more
europepmc   +2 more sources

An improved pathway for autonomous bioluminescence imaging in eukaryotes. [PDF]

Nat Methods
The discovery of the bioluminescence pathway in the fungus Neonothopanus nambi enabled engineering of eukaryotes with self-sustained luminescence. However, the brightness of luminescence in heterologous hosts was limited by performance of the native ...
Shakhova ES, Karataeva TA, Markina NM, Mitiouchkina T, Palkina KA, Perfilov MM, Wood MG, Hoang TT, Hall MP, Fakhranurova LI, Alekberova AE, Malyshevskaia AK, Gorbachev DA, Bugaeva EN, Pletneva LK, Babenko VV, Boldyreva DI, Gorokhovatsky AY, Balakireva AV, Gao F, Choob VV, Encell LP, Wood KV, Yampolsky IV, Sarkisyan KS, Mishin AS.   +25 more
europepmc   +2 more sources

Bioluminescent Xanthomonas hortorum pv. gardneri as a Tool to Quantify Bacteria in Planta, Screen Germplasm, and Identify Infection Routes on Leaf Surfaces

Frontiers in Plant Science, 2021
Imaging technology can provide insight into biological processes governing plant-pathogen interactions. We created and used a bioluminescent strain of Xanthomonas hortorum pv.
Eduardo Bernal, Loïc Deblais, Gireesh Rajashekara, David M. Francis   +3 more
doaj   +1 more source

Multi-Modal Multi-Spectral Intravital Macroscopic Imaging of Signaling Dynamics in Real Time during Tumor–Immune Interactions

Cells, 2021
A major obstacle in studying the interplay between cancer cells and the immune system has been the examination of proposed biological pathways and cell interactions in a dynamic, physiologically relevant system in vivo.
Tracy W. Liu, Seth T. Gammon, David Fuentes, David Piwnica-Worms   +3 more
doaj   +1 more source

Bioluminescence Imaging [PDF]

Proceedings of the American Thoracic Society, 2005
Abstract Bioluminescence refers to the process of visible light emission in living organisms. Bioluminescence imaging is a powerful methodology that has been developed over the last decade as a tool for molecular imaging of small laboratory animals, enabling the study of ongoing biological processes in vivo.
Ruxana T, Sadikot, Timothy S, Blackwell
openaire   +2 more sources

Molecular Design of d-Luciferin-Based Bioluminescence and 1,2-Dioxetane-Based Chemiluminescence Substrates for Altered Output Wavelength and Detecting Various Molecules

Molecules, 2021
Optical imaging including fluorescence and luminescence is the most popular method for the in vivo imaging in mice. Luminescence imaging is considered to be superior to fluorescence imaging due to the lack of both autofluorescence and the scattering of ...
Hideo Takakura
doaj   +1 more source

All-in-one theranostic nano-platform based on polymer nanoparticles for BRET/FRET-initiated bioluminescence imaging and synergistically anti-inflammatory therapy for ulcerative colitis

Journal of Nanobiotechnology, 2022
Background Ulcerative colitis (UC), a subtype of inflammatory bowel disease (IBD), has evolved into a global burden given its high incidence. There is a clinical need to create better diagnostic and therapeutic approaches to UC.
X. Yan, Chunhua Yang, Mei Yang, Yana Ma, Yuanyuan Zhang, Yujie Zhang, Cui Liu, Qiuran Xu, K. Tu, Mingzhen Zhang   +9 more
semanticscholar   +1 more source

Multi-Modal Multi-Spectral Intravital Microscopic Imaging of Signaling Dynamics in Real-Time during Tumor–Immune Interactions

Cells, 2021
Intravital microscopic imaging (IVM) allows for the study of interactions between immune cells and tumor cells in a dynamic, physiologically relevant system in vivo. Current IVM strategies primarily use fluorescence imaging; however, with the advances in
Tracy W. Liu, Seth T. Gammon, David Piwnica-Worms   +2 more
doaj   +1 more source

Evaluation of NanoLuc substrates for bioluminescence imaging of transferred cells in mice.

Journal of Photochemistry and Photobiology. B: Biology, 2021
NanoLuc luciferase recently gained popularity due to its small size and superior bioluminescence performance. For in vivo imaging applications, NanoLuc has been limited by its substrate furimazine, which has low solubility and bioavailability. Herein, we
Natasa Gaspar, Joel R Walker, Giorgia Zambito, Kranthi Marella-Panth, C. Lowik, Thomas A. Kirkland, L. Mezzanotte   +6 more
semanticscholar   +1 more source

Bacteria-Based Live Vehicle for In Vivo Bioluminescence Imaging.

Analytical Chemistry, 2021
The anticancer therapy strategy mediated by tumor-targeting bacteria needs better visualization tools for imaging and monitoring bacteria in vivo. The probiotic strain Escherichia coli Nissle 1917 (EcN), one of the tumor-targeting bacteria, leads to the ...
Tianyu Jiang, Xingye Yang, Geng Li, Xiaohan Zhao, Tao Sun, Rolf Müller, Hailong Wang, Minyong Li, Youming Zhang   +8 more
semanticscholar   +1 more source