Results 41 to 50 of about 746,277 (164)

Proteomics-on-a-chip for Biomarker discovery [PDF]

, 2007
In proteomics research still two-dimensional gel electrophoresis (2D-GE) is currently used for biomarker discovery. We applied free flow electrophoresis (FFE) separation technology combined with biomolecular interaction sensing using Surface Plasmon ...
Berg, Albert van den, Eijkel, Jan, Kohlheyer, Dietrich, Schasfoort, Richard B.M., Schlautmann, Stefan   +4 more
core   +1 more source

IGFBP-5 as a biomarker of de-differentiation in hepatocytes [PDF]

, 2011
Describes IGFBP-5 as a biomarker of de-differentiation in hepatocytes presented at the 47th Congress of the European-Societies-of ...
Flint, David, Grant, Mary, Henderson, Catherine, Large, Emma   +3 more
core   +1 more source

Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer

Nature Communications, 2020
The exclusion of T cells from solid tumours is a potentially important mechanism that regulates whether or not cancer patients respond well to checkpoint blocking immunotherapies.
Mélanie Desbois, Akshata R. Udyavar, Lisa Ryner, Cleopatra Kozlowski, Yinghui Guan, Milena Dürrbaum, Shan Lu, Jean-Philippe Fortin, Hartmut Koeppen, James Ziai, Ching-Wei Chang, Shilpa Keerthivasan, Marie Plante, Richard Bourgon, Carlos Bais, Priti Hegde, Anneleen Daemen, Shannon Turley, Yulei Wang   +18 more
doaj   +1 more source

On the trophic fate of Phaeocystis pouchetii: VII. Sterols and fatty acids reveal sedimentation of Phaocystis-derived organic matter via krill fecal strings [PDF]

, 2001
As part of a joint project on the fate of phytoplankton in Balsfjorden in Northern Norway, we investigated the trophic fate and sedimentation potential of Phaeocystis pouchetii by tracing the transition of biomarker patterns from a phytoplankton bloom to
Hamm, Christian, Reigstad, M., Wassmann, P., Wexels-Riser, C.   +3 more
core  

A cfDNA methylation-based tissue-of-origin classifier for cancers of unknown primary

Nature Communications
Cancers of Unknown Primary (CUP) remains a diagnostic and therapeutic challenge due to biological heterogeneity and poor responses to standard chemotherapy.
Alicia-Marie Conway, Simon P. Pearce, Alexandra Clipson, Steven M. Hill, Francesca Chemi, Dan Slane-Tan, Saba Ferdous, A. S. Md Mukarram Hossain, Katarzyna Kamieniecka, Daniel J. White, Claire Mitchell, Alastair Kerr, Matthew G. Krebs, Gerard Brady, Caroline Dive, Natalie Cook, Dominic G. Rothwell   +16 more
doaj   +1 more source

Fine-grained cell-type specific association studies with human bulk brain data using a large single-nucleus RNA sequencing based reference panel

Scientific Reports, 2023
Brain disorders are leading causes of disability worldwide. Gene expression studies provide promising opportunities to better understand their etiology but it is critical that expression is studied on a cell-type level.
Edwin J. C. G. van den Oord, Karolina A. Aberg   +1 more
doaj   +1 more source

Fluid biomarkers and risk of neurodegenerative disease in retired athletes with multiple concussions: results from the International Concussion and Head Injury Research Foundation Brain health in Retired athletes Study of Ageing and Impact-Related Neurodegenerative Disease (ICHIRF-BRAIN study)

BMJ Open Sport & Exercise Medicine, 2022
Objectives To investigate the association and utility of blood plasma markers of neurodegeneration in a population of retired athletes self-reporting multiple concussions throughout a sporting career. It is hypothesised that this type of athletic history
Michael Turner, Henrik Zetterberg, Amanda Heslegrave, Owen James Swann   +3 more
doaj   +1 more source

Modern spatial sea-ice variability in the central Arctic Ocean and adjacent marginal seas: Reconstruction from biomarker data [PDF]

, 2012
Sea ice is a fundamental component of Earth’s climate system, contributing to heat reduction (albedo) and deep-water formation. In order to understand processes controlling the recent dramatic reduction in Arctic sea-ice cover, it is essential to ...
Fahl, Kirsten, Meheust, Marie, Müller, Juliane, Stein, Rüdiger, Xiao, Xiaotong   +4 more
core  

Basal-like breast cancer: molecular profiles, clinical features and survival outcomes

BMC Medical Genomics, 2017
Background Basal-like constitutes an important molecular subtype of breast cancer characterised by an aggressive behaviour and a limited therapy response. The outcome of patients within this subtype is, however, divergent.
Heloisa H. Milioli, Inna Tishchenko, Carlos Riveros, Regina Berretta, Pablo Moscato   +4 more
doaj   +1 more source

Insulin-like growth factor binding protein-5 as a biomarker for detection of early liver disease [PDF]

, 2011
Study identifying an Insulin-like growth factor binding protein-5 as a biomarker for detection of early liver disease presented at the annual congress of the british toxicology ...
Anne Pryde, David J. Flint, Emma M. Large, Filippi, John N. Plevris, M. Helen Grant, Nakamura, Sokolovic, Yasuoka, Yasuoka   +9 more
core   +1 more source