Results 81 to 90 of about 2,295,331 (380)
Ploidy determination across the genome has been challenging for low-pass-WGS tumor-only samples. We present BACDAC, a method that calculates tumor ploidy down to 1.2X effective tumor coverage.
Sarah H. Johnson+9 more
doaj +1 more source
Alternative Complement Pathway Inhibition by Lampalizumab
Purpose: Lampalizumab, an antigen-binding fragment of a humanized monoclonal antibody directed against complement factor D (CFD), is designed to treat geographic atrophy (GA) secondary to age-related macular degeneration.
Rose Edmonds, MS+3 more
doaj +1 more source
Modern spatial sea-ice variability in the central Arctic Ocean and adjacent marginal seas: Reconstruction from biomarker data [PDF]
Sea ice is a fundamental component of Earth’s climate system, contributing to heat reduction (albedo) and deep-water formation. In order to understand processes controlling the recent dramatic reduction in Arctic sea-ice cover, it is essential to ...
Fahl, Kirsten+4 more
core
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona+4 more
wiley +1 more source
The Role of the Complement Pathway in Clinical Progression of Geographic Atrophy
Purpose: To investigate the relationship between complement pathway activities and progression of geographic atrophy (GA) secondary to age-related macular degeneration in samples collected from patients enrolled in the Chroma and Spectri trials.
Rose Edmonds, MS+3 more
doaj +1 more source
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura+8 more
wiley +1 more source
Biomarkers in mesothelioma [PDF]
Mesothelioma is an aggressive cancer of pleural and peritoneal cells that is difficult to diagnose and monitor. Numerous studies have attempted to identify a blood- or pleural fluid-based biomarker that could be used in the diagnostic pathway. More recently, there has been interest in the ability of serum/plasma biomarkers to monitor mesothelioma ...
Arnold, David T, Maskell, Nick A
openaire +5 more sources
Background Amyloid-β 1–42 (Aβ1–42) peptide is a well-established cerebrospinal fluid (CSF) biomarker for Alzheimer’s disease (AD). Reduced levels of Aβ1–42 are indicative of AD, but significant variation in the absolute concentrations of this analyte has
Stephen P. Schauer+6 more
doaj +1 more source
The PD-1/PD-L1 Pathway: A Perspective on Comparative Immuno-Oncology
The programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) pathway mainly attracted attention in immuno-oncology, leading to the development of immune checkpoint therapy.
Sandra Schöniger, Bharat Jasani
doaj +1 more source
IGFBP-5 as a biomarker of de-differentiation in hepatocytes [PDF]
Describes IGFBP-5 as a biomarker of de-differentiation in hepatocytes presented at the 47th Congress of the European-Societies-of ...
Flint, David+3 more
core +1 more source