Results 21 to 30 of about 411 (173)

Liquid biopsy for non-invasive monitoring of patients with kidney transplants

Frontiers in Transplantation, 2023
The current tools for diagnosing and monitoring native kidney diseases as well as allograft rejection in transplant patients are suboptimal. Creatinine and proteinuria are non-specific and poorly sensitive markers of injury.
Anthony Nassar, Katharine Cashman, Shreya Rao, Maribel Dagher, Connor O’Brien, John Afif, Paolo Cravedi, Jamil R. Azzi   +7 more
doaj   +1 more source

Acute Rheumatic Fever Diagnostic Network (ARC Network) clinical recruitment protocol

BMJ Open
Introduction Rheumatic heart disease, a major cause of morbidity and mortality in low- and middle-income countries, results from acute rheumatic fever (ARF), for which no diagnostic test currently exists.
Craig Sable, Jonathan Carapetis, Andrea Zawacki Beaton, Maria Carmo Pereira Nunes, Joshua Reginald Francis, Anna Ralph, Tom Parks, Rachel Sarnacki, Ndate Fall, Masood Sadiq, Rachel Webb, Nicole J Moreland, Amy Sanyahumbi, Asha Clare Bowen, Samantha Buonfiglio, Christopher Gorman, Renata Fonseca Mendoza, Ela Fernandes, Casey P Shannon, Scott Tebbutt   +19 more
doaj   +1 more source

Characterization of barriers and facilitators to recruiting veterans to participate in Alzheimer's disease biomarker research: a cross‐sectional survey

Alzheimer’s & Dementia: Behavior & Socioeconomics of Aging
INTRODUCTION This study examined veteran‐specific factors affecting interest in Alzheimer's disease and related dementias (ADRD) biomarker research participation.
Ralph Richards, Ananya Balaji, Crystal Shipp, Mary Aurtrey, Angel Ingram, Richard Williams, Andrew Tackett, Johanne Eliacin, Sujuan Gao, David Johnson, Emily Nicklett, Omolola A. Adeoye‐Olatunde, Andrew Saykin, Sophia Wang   +13 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Beyond the label “major depressive disorder”—detailed characterization of study population matters for EEG-biomarker research

Frontiers in Neuroscience
IntroductionMajor Depressive Disorder (MDD) is a prevalent, multi-faceted psychiatric disorder influenced by a plethora of physiological and environmental factors. Neuroimaging biomarkers such as diagnosis support systems based on electroencephalography (
Roman Mähler, Roman Mähler, Alexandra Reichenbach, Alexandra Reichenbach   +3 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Association between trust of researchers and willingness to participate in Alzheimer's disease biomarker research

Alzheimer’s & Dementia: Behavior & Socioeconomics of Aging
Introduction The study examined the relationship between trust of researchers in research‐naïve participants, including those at higher risk, and interest in Alzheimer's disease and related dementias (ADRD) biomarker research participation.
Laureen Raelly‐Muze, Taylor Etchison, Adele Crouch, Johanne Eliacin, Angelina Polsinelli, Sujuan Gao, Sarah Van Heiden, Joseph Asper, Caprice Elliott, Ralph Richards, Mollie Richards, Christopher Campbell, Hugh Hendrie, Pamella Shaw, Omolola Adeoye‐Olatunde, Shannon Risacher, Andrew Saykin, Sophia Wang   +17 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source