Results 41 to 50 of about 411 (173)

The Role of Cystatin C in the Prediction of Contrast-Induced Acute Kidney Injury Following Coronary Procedures: A Systematic Review

Reviews in Cardiovascular Medicine
Background: Contrast-induced acute kidney injury (CI-AKI) represents a significant cause of acute kidney injury (AKI) and accounts for 11% of all cases.
Azad Mojahedi, Andreas P. Kalogeropoulos, On Chen, Hal Skopicki   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Acromiohumeral Distance as a Diagnostic and Prognostic Biomarker for Shoulder Disorders: A Systematic Review—Acromiohumeral Distance and Shoulder Disorders

Journal of Functional Morphology and Kinesiology
Objectives: The acromiohumeral distance (AHD) is widely used to evaluate subacromial pathology, particularly rotator cuff–related disorders. However, substantial heterogeneity exists across studies in imaging protocols, measurement definitions, and ...
Luis Alfonso Arráez-Aybar, Carlos Miquel García-de-Pereda-Notario, Luis Palomeque-Del-Cerro, Juan José Montoya-Miñano   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Lab-on-a-Chip Platforms for Detection of Cardiovascular Disease and Cancer Biomarkers

Sensors, 2017
Cardiovascular disease (CVD) and cancer are two leading causes of death worldwide. CVD and cancer share risk factors such as obesity and diabetes mellitus and have common diagnostic biomarkers such as interleukin-6 and C-reactive protein.
Jiandong Wu, Meili Dong, Susy Santos, Claudio Rigatto, Yong Liu, Francis Lin   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Barking up the wrong biomarker? Correspondence to Shobeiri et al. (2022) “Serum and plasma levels of brain-derived neurotrophic factor in individuals with eating disorders (EDs): a systematic review and meta-analysis”

Journal of Eating Disorders, 2022
Despite intensified research efforts into the underlying (neuro-)biology of eating disorders (EDs), only few reliable biomarkers of diagnostic or prognostic value have been identified to date.
Jonas L. Steinhäuser, Marie-Louis Wronski, Johanna L. Keeler, Stefan Ehrlich, Joseph A. King   +4 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Advancements in biomarker techniques for precision and safety in facial nerve identification during head and neck surgeries: a comprehensive review

JPRAS Open
Objective: This review aimed to evaluate biomarkers’ efficacy in enhancing facial nerve identification during head and neck surgical procedures. It summarized the literature on biomarker techniques for intraoperative visualization of the facial nerve ...
Cesar Raizer, Milanie Milan, Reina Ibrahim, Joseph El Bachour, Abdelrazzak Kerhani, Gregory Nicolas   +5 more
doaj   +1 more source

Circulating cell-free DNA as a biomarker in the diagnosis and prognosis of colorectal cancer

Brazilian Journal of Pharmaceutical Sciences, 2018
Colorectal cancer (CRC) is a disease without evident clinical symptoms in early stages, leading to late diagnosis and disease management. Current diagnostic and prognostic tools require invasive procedures and circulating molecular biomarkers fail to ...
Isadora Bernardo David de Oliveira, Rosario Dominguez Crespo Hirata   +1 more
doaj   +1 more source