Results 51 to 60 of about 411 (173)

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Crosslinking Salivary Diagnosis with Non-Invasive Insights to Oral Pathology: Novel Systematic Insights to Personalized Medicine in Disease Management

Pakistan Armed Forces Medical Journal
Objective: To explore the integration of salivary biomarkers, histopathological validation, and advanced imaging for precision diagnosis and management of oral diseases. Methodology: A systematic review was conducted in accordance with the PRISMA 2020
Rehana Kausar, Attia Batool, Ashfaq Ahmad Shah Bukhari, Abdul Rehman Khalil Shaikh, Abdul Aleem, Madeeha Minhas, Muhammad Hussain   +6 more
doaj   +1 more source

The Integrated Oncology Program of the Italian Ministry of Health

The International Journal of Biological Markers, 2009
In 2007, an Italian cancer research group proposed a specific concerted action aimed at the “analytical and clinical validation of new biomarkers for early diagnosis: Network, resources, methodology, quality control, and data analysis.” The proposal ...
Angelo Paradiso Dr., Anita Mangia, Claudio Orlando, Paolo Verderio, Maurizio Belfiglio, Antonio Marchetti, Lucio Bertario, Gennaro Chiappetta, Massimo Gion, Gian Paolo Tonini, Franca Podo, Amina Vocaturo, Rosella Silvestrini   +12 more
doaj   +1 more source

Steroidomics for the Prevention, Assessment, and Management of Cancers: A Systematic Review and Functional Analysis

Metabolites, 2019
Steroidomics, an analytical technique for steroid biomarker mining, has received much attention in recent years. This systematic review and functional analysis, following the PRISMA statement, aims to provide a comprehensive review and an appraisal of ...
Nguyen Hoang Anh, Nguyen Phuoc Long, Sun Jo Kim, Jung Eun Min, Sang Jun Yoon, Hyung Min Kim, Eugine Yang, Eun Sook Hwang, Jeong Hill Park, Soon-Sun Hong, Sung Won Kwon   +10 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

FKBP5 gene - current knowledge, new approach and possible biomarker function: a narrative review

Journal of Education, Health and Sport
Introduction  Over the past few decades, the level of interest in the use of complex molecular pathways in the course of various diseases has increased significantly.
Sven Solisch, Agata Boczar, Patryk Dryja, Bianka Solisch, Jakub Jarmołowicz   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Non-Skeletal Activities of Vitamin D: From Physiology to Brain Pathology

Medicina, 2019
Vitamin D is a secosteroid hormone regulating the expression of almost 900 genes, and it is involved in the regulation of calcium and phosphate metabolism, immune response, and brain development.
Giulia Bivona, Luisa Agnello, Chiara Bellia, Giorgia Iacolino, Concetta Scazzone, Bruna Lo Sasso, Marcello Ciaccio   +6 more
doaj   +1 more source