Results 51 to 60 of about 2,113,927 (314)
BMC CancerBackground This study aims to investigate the expression of UBQLN1 in lung cancer (LC) tissue and the diagnostic capability of autoantibody to UBQLN1 (anti-UBQLN1) in the detection of LC and the discrimination of pulmonary nodules (PNs).
Yulin Wang +12 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Breast Cancer ResearchBackground Triple-negative breast cancer (TNBC) is a subtype of breast cancer which has the poorest prognosis, with high recurrence and metastasis rates. ZNF503 (Zinc finger elbow-related proline domain protein 2) was a transcriptional factor involved in
Siyu Liu +7 more
doaj +1 more source
Aberrant Expression and Prognostic Potential of IL-37 in Human Lung Adenocarcinoma
Biomedicines, 2022 Interleukin-37 (IL-37) is a relatively new IL-1 family cytokine that, due to its immunoregulatory properties, has lately gained increasing attention in basic and translational biomedical research.
Panayiota Christodoulou +7 more
doaj +1 more source
MicroRNAs As Biomarkers of Brain Tumors
Cancer Management and ResearchBrain tumors still remain a deadly cancer that, in most cases, is difficult to diagnose at an earlier stage. Therefore, it is necessary to develop rapid, sensitive methods for detecting cancer biomarkers. Such a biomarker may be a microRNA which expression level in body fluids is strongly correlated with cancer.
Jelski Wojciech, Barbara Mroczko
openaire +4 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Proteomic analysis of biomarkers associated with immunotherapy in murine tumour models [PDF]
, 2009 Emergence of proteomics and high-throughput technologies has allowed the identification of protein expression patterns of disease that potentially hold clinical importance in predictive medicine.
Vafadar-Isfahani, B
core
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Lipid-loaded macrophages as new therapeutic target in cancer
Journal for ImmunoTherapy of Cancer, 2022 Macrophages are main players of the innate immune system. They show great heterogeneity and play diverse functions that include support to development, sustenance of tissue homeostasis and defense against infections.
Ping-Chih Ho +7 more
doaj +1 more source
Circulating Tumors Cells as Biomarkers [PDF]
The Cancer Journal, 2011 Personalized cancer medicine requires the development of tumor-specific biomarkers to optimize selection of targeted therapies and to better assess response to therapy. Current efforts in several tumor types have shown that patients in whom circulating tumor cells (CTCs) are detected have an inferior prognosis relative to those in whom CTCs are not ...
Daniel C, Danila +3 more
openaire +2 more sources