Results 61 to 70 of about 2,640,873 (286)

Cancer biomarker development from basic science to clinical practice [PDF]

open access: yes, 2018
The amount of published literature on biomarkers has exponentially increased over the last two decades. Cancer biomarkers are molecules that are either part of tumour cells or secreted by tumour cells.
Ali, Asif   +3 more
core  

ST2 and Multimarker Testing in Acute Decompensated Heart Failure [PDF]

open access: yes, 2015
Most data on heart failure biomarkers have been derived from patient cohorts with chronic disease. However, risk prediction in patients admitted with acute decompensated heart failure (ADHF) remains a challenge.
Antoni, Md   +7 more
core   +1 more source

A combined clinical and biomarker approach to predict diuretic response in acute heart failure [PDF]

open access: yes, 2015
Background: Poor diuretic response in acute heart failure is related to poor clinical outcome. The underlying mechanisms and pathophysiology behind diuretic resistance are incompletely understood.
Bloomfield, Daniel M.   +16 more
core   +4 more sources

Orthogonal quantification of soluble inducible T-cell costimulator (ICOS) in healthy and diseased human serum

open access: yesJournal of Pharmaceutical Analysis, 2022
Inducible T-cell costimulator (ICOS), a homodimeric protein expressed on the surface of activated T-cells, is being investigated as a potential therapeutic target to treat various cancers.
Kevin McKinski   +5 more
doaj  

Deep Learning Predicts Biomarker Status and Discovers Related Histomorphology Characteristics for Low-Grade Glioma [PDF]

open access: yesarXiv, 2023
Biomarker detection is an indispensable part in the diagnosis and treatment of low-grade glioma (LGG). However, current LGG biomarker detection methods rely on expensive and complex molecular genetic testing, for which professionals are required to analyze the results, and intra-rater variability is often reported.
arxiv  

Serum micrornas as novel biomarkers for primary sclerosing cholangitis and cholangiocarcinoma [PDF]

open access: yes, 2016
The diagnosis of primary sclerosing cholangitis (PSC) is difficult due to the lack of sensitive and specific biomarkers, as is the early diagnosis of cholangiocarcinoma (CC), a complication of PSC.
Alpini, Gianfranco   +17 more
core   +2 more sources

Biomarkers of sepsis: time for a reappraisal

open access: yesCritical Care, 2020
Introduction Sepsis biomarkers can have important diagnostic, therapeutic, and prognostic functions. In a previous review, we identified 3370 references reporting on 178 different biomarkers related to sepsis.
C. Pierrakos   +4 more
semanticscholar   +1 more source

The dual amylin and calcitonin receptor agonist KBP-336 elicits a unique combination of weight loss, antinociception and bone protection – a novel disease-modifying osteoarthritis drug

open access: yesArthritis Research & Therapy
Background Despite the extensive research to provide a disease-modifying osteoarthritis drug (DMOAD), there is still no approved DMOAD. Dual amylin and calcitonin receptor agonists (DACRA) can provide metabolic benefits along with antinociceptive and ...
Khaled Elhady Mohamed   +6 more
doaj   +1 more source

Sprifermin (rhFGF18) modulates extracellular matrix turnover in cartilage explants ex vivo

open access: yesJournal of Translational Medicine, 2017
Background Sprifermin (recombinant human fibroblast growth factor 18) is in clinical development as a potential disease-modifying osteoarthritis drug (DMOAD).
Ditte Reker   +7 more
doaj   +1 more source

Characterization of retinal function and structure in the MPTP murine model of Parkinson’s disease

open access: yesScientific Reports, 2022
In addition to well characterized motor symptoms, visual disturbances are increasingly recognized as an early manifestation in Parkinson’s disease (PD). A better understanding of the mechanisms underlying these changes would facilitate the development of
Katie K. N. Tran   +7 more
doaj   +1 more source

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