Results 61 to 70 of about 1,320,970 (304)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Advances in graphene-based 2D materials for tendon, nerve, bone/cartilage regeneration and biomedicine

iScience
Summary: Two-dimensional (2D) materials, especially graphene-based materials, have important implications for tissue regeneration and biomedicine due to their large surface area, transport properties, ease of functionalization, biocompatibility, and ...
Yuxin Gao, Xu Wang, Cunyi Fan
doaj   +1 more source

In Diamond Health [PDF]

, 2008
In contrast to the sparkling gemstone, diamond-like carbon (DLC) is a thin film coating that is dense, inert, low friction and hard wearing. Interdisciplinary research, involving materials scientists, physicists, mechanical engineers, biomedical ...
Anson, AW, Jones, BJ
core  

Biomedical and microbiological applications of bio-based porous materials: a review [PDF]

, 2017
Extensive employment of biomaterials in the areas of biomedical and microbiological applications is considered to be of prime importance. As expected, oil based polymer materials were gradually replaced by natural or synthetic biopolymers due to their ...
Abdelaal, Cheng Chuah, Ghosh, Gunathilake, Gupta, Jovanović-Malinovska, Kailasapathy, Kazemzadeh Narbat, Kuan Ching, Luqman Abdullah, Mohd, Nedovic, O’brien, Pichatborvonkul, Stolarzewicz, T. Udenni Gunathilake, Yern Ching, Zanjani   +17 more
core   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Inflammatory targeted nanoplatform incorporated with antioxidative nano iron oxide to attenuate ulcerative colitis progression

iScience
Summary: Antioxidative nanomaterials with reactive oxygen species (ROS) scavenging capabilities hold promise for the treatment of ulcerative colitis (UC).
Haojun Chen, Wei Sun, Can Li, Qiuyang Wang, Xucai Wang, Yingjie Du, Wenbo Chen, Min Wang, Caoxing Huang, Rong Wang   +9 more
doaj   +1 more source

Highly cross‐linked polyethylene is the new ‘gold standard’ bearing material for total hip arthroplasty

Biosurface and Biotribology, 2021
Conventional polyethylene is not used much in total hip arthroplasty (THA); it has been supplanted by oxidation‐resistant cross‐linked polyethylene (≥50 kGy irradiation). However, studies persist that de‐emphasize or ignore cross‐linked polyethylene.
John B. Medley
doaj   +1 more source

Metal-insulator Transition (MIT) Materials for Biomedical Applications [PDF]

, 2019
Transitional metal oxides get considerable interest in electronics and other engineering applications over few decades. These materials show several orders of magnitude metal-insulator transition (MIT) triggered by external stimuli.
Coutu, Ronald A., Jr., Mahanta, Protap, Munna, Mohiuddin   +2 more
core   +1 more source

Facile preparation of agarose-chitosan hybrid materials and nanocomposite ionogels using an ionic liquid via dissolution, regeneration and sol-gel transition [PDF]

, 2014
We report simultaneous dissolution of agarose (AG) and chitosan (CH) in varying proportions in an ionic liquid (IL), 1-butyl-3-methylimidazolium chloride [C4mim][Cl].
Kumar, Arvind, Rao, K. Srinivasa, Trivedi, Tushar J.   +2 more
core   +2 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source