Results 151 to 160 of about 116,047 (273)

Innovative Method for Evaluating the Optical Properties of Liquid–Liquid Phase Separations Using Laser Scanning Microscopic Spectroscopy

Microscopy Research and Technique, EarlyView.
The LLPS phenomenon in the optoDroplet method can be discerned through the use of fluorescent molecular spectroscopy, which enabled the distinction between droplet formation and gelation. ABSTRACT Liquid–liquid phase separation (LLPS) plays a central role in intracellular compartmentalization and gene regulation.
Johbu Itoh, Natsuko Fujii, Saori Kohara, Masatoshi Ito, Naoto Suzuki, Eiichiro Nagata   +5 more
wiley   +1 more source

Molecular Glue Degraders in Early Development for Cancer Therapy

Medicinal Research Reviews, EarlyView.
ABSTRACT Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein‐protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E3 ubiquitin ligase, they ...
E. Sila Ozdemir, Hyunbum Jang, Ozlem Keskin, Attila Gursoy, Ruth Nussinov   +4 more
wiley   +1 more source

Main‐chain polyfullerenes: Taking fullerene to the next dimension

Polymer International, EarlyView.
This short review appraises main‐chain polyfullerenes. Their slow development over 30 years has suddenly boomed with a rapid growth due to exciting developments in solar energy. Abstract This mini‐review gives an overview of the development, chemistry, properties and applications of main‐chain polyfullerenes.
Marco Antônio GB Gomes, Orisson Ponce Gomes, Patricia Targon Campana, Didier Bégué, Roger C Hiorns   +4 more
wiley   +1 more source

The Long Trajectory of Rubber Physics: 3500+ Years and Counting

Journal of Polymer Science, EarlyView.
Natural rubber's trajectory is traced from Mesoamerican use of Castilla elastica through vulcanization and the pneumatic tire to macromolecular physics and modern solid‐state refrigeration. Illustrations of C. elastica and an H. brasiliensis plantation frame the historical progression from indigenous material, then industrial crop and on to advanced ...
Gregory B. McKenna
wiley   +1 more source

Protein compactness and interaction valency define the architecture of a biomolecular condensate across scales. [PDF]

Elife, 2023
Polyansky AA, Gallego LD, Efremov RG, Köhler A, Zagrovic B.   +4 more
europepmc   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Kidney-specific WNK1 amplifies kidney tubule responsiveness to potassium via WNK body condensates

The Journal of Clinical Investigation
To maintain potassium homeostasis, the kidney’s distal convoluted tubule (DCT) evolved to convert small changes in blood [K+] into robust effects on salt reabsorption.
Cary R. Boyd-Shiwarski, Rebecca T. Beacham, Jared A. Lashway, Katherine E. Querry, Shawn E. Griffiths, Daniel J. Shiwarski, Sophia A. Knoell, Nga H. Nguyen, Lubika J. Nkashama, Melissa N. Valladares, Anagha Bandaru, Allison L. Marciszyn, Jonathan Franks, Mara Sullivan, Simon C. Watkins, Aylin R. Rodan, Chou-Long Huang, Sean D. Stocker, Ossama B. Kashlan, Arohan R. Subramanya   +19 more
doaj   +1 more source

Dissecting Rate-Limiting Processes in Biomolecular Condensate Exchange Dynamics. [PDF]

PRX Life
Kliegman R, Kengmana E, Schulman R, Zhang Y.   +3 more
europepmc   +1 more source

Notoginsenoside R2 Antagonizes Renal Interstitial Fibrosis by Regulating Fatty Acid Oxidation via the CASP2/ALDH3A1 Axis

Phytotherapy Research, EarlyView.
Proposed mechanism by which notoginsenoside R2 (NGR2) attenuates renal interstitial fibrosis. In injured renal tubular epithelial cells, CASP2 downregulation and enhanced ubiquitin‐dependent degradation of ALDH3A1 disrupt mitochondria‐associated endoplasmic reticulum membranes (MAMs) and impair fatty acid oxidation (FAO), leading to lipid accumulation ...
Guanting Chen, Tao Li, Zhenzhen Wang, Hao Zhao, Xiaoxia Xun, Yijiao Wang, Shiyuan Jiang, Qing Zhang, Weiwei Sun, Kang Yang, Yaoxian Wang   +10 more
wiley   +1 more source

Carbon dots in electrochemiluminescence: Mechanisms, interface engineering, and bioanalytical applications

Responsive Materials, EarlyView.
Carbon dots are emerging as versatile electrochemiluminescent nanomaterials whose structure, surface states, and interfacial design jointly determine ECL pathways and performance. This review highlights how mechanistic understanding and materials engineering enable programmable CD‐ECL systems for bioanalysis, imaging, and future intelligent analytical ...
Yuhan Zhao, Zixuan Chen, Jun‐Jie Zhu
wiley   +1 more source