Results 101 to 110 of about 5,912 (181)

Linoleic Acid Enhances Murine Natural Killer Cell Function In Vitro but Compromises Mitochondrial Bioenergetic Function During Retroviral Infection

Immunology, EarlyView.
Natural Killer (NK) cells are potent effectors against virus‐infected and tumour cells. During Friend Virus (FV) infection, fatty acid metabolism supports NK‐cell effector functions. Here, we found that NK cells from FV‐infected mice preferentially take up linoleic acid (LA), which reduced proliferation, mitochondrial function, and increased reactive ...
Vaasudevan Sridhar, Simone Schimmer, Tanja Werner, Rachel Giesen, Mohamed Saad, Constantin P. Krempe, Sven W. Meckelmann, Ulf Dittmer, Elisabeth Littwitz‐Salomon   +8 more
wiley   +1 more source

Nitrile-aminothiol bioorthogonal near-infrared fluorogenic probes for ultrasensitive in vivo imaging

Nature Communications
Bioorthogonal chemistry-mediated self-assembly holds great promise for dynamic molecular imaging in living organisms. However, existing approaches are limited to nanoaggregates with ‘always-on’ signals, suffering from high signal-to-background ratio (SBR)
Weiping Xu, Shujuan Yi, Jie Liu, Yuyan Jiang, Jiaguo Huang   +4 more
doaj   +1 more source

A Ruthenium(CAAC‐5) Olefin Metathesis Catalyst for Bioconjugation

Angewandte Chemie International Edition, Volume 65, Issue 45, 2 November 2026.
The aqueous instability of ruthenium catalysts restricts olefin metathesis in biological media. A Ru(CAAC‐5) complex bearing an aniline handle is reported that remains active under biologically relevant conditions and enables bioconjugation to proteins, peptides, and an artificial metalloenzyme, providing a robust platform for olefin metathesis in ...
Damian Alexander Graf, Mikhail Boym, María Álvarez, Tsvetan Kardashliev, Thomas R. Ward   +4 more
wiley   +1 more source

Farnesyltransferase Enables Modular Assembly of Dual‐Functional Nanobody Conjugates for in Vivo Imaging of Inflammation

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy, Yoon Ho Lee, Ali Salehi Farid, Heydar Moravej, Sina Djafari Rouhani, Jennifer E. Rowley, Mohammad Rashidian, Mark D. Distefano   +7 more
wiley   +2 more sources

Bio-inspired biorthogonal compartmental microparticles for tumor chemotherapy and photothermal therapy

Journal of Nanobiotechnology
Microcarrier is a promising drug delivery system demonstrating significant value in treating cancers. One of the main goals is to devise microcarriers with ingenious structures and functions to achieve better therapeutic efficacy in tumors.
Qingfei Zhang, Gaizhen Kuang, Li Wang, Lu Fan, Yechao Zhou, Luoran Shang, Yuanjin Zhao, Weijian Sun   +7 more
doaj   +1 more source

Trans-cyclooctene—a Swiss army knife for bioorthogonal chemistry: exploring the synthesis, reactivity, and applications in biomedical breakthroughs

EJNMMI Radiopharmacy and Chemistry
Background Trans-cyclooctenes (TCOs) are highly strained alkenes with remarkable reactivity towards tetrazines (Tzs) in inverse electron-demand Diels–Alder reactions.
Karuna Adhikari, Maarten Vanermen, Gustavo Da Silva, Tim Van den Wyngaert, Koen Augustyns, Filipe Elvas   +5 more
doaj   +1 more source

Chelation‐Assisted Metal‐Catalyzed Ligation and Cleavage Reactions for Chemical Biology

European Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.
Chelation‐assisted transition metal catalysis has emerged as a promising complement to bioorthogonal click chemistry for studying biological processes. By pre‐organizing catalytic metal centers, designed coordinating substrates enhance reactivity and biocompatibility, enabling site‐selective ligation and decaging reactions in complex biological media ...
Emilie Plantiveau, Maxime Riberaud, Frédéric Taran, Antoine Sallustrau   +3 more
wiley   +1 more source

Synthesis of Cysteine–Fluorophore Conjugates by Visible‐Light‐Promoted Thiol–Ene Coupling Using Organic Photocatalysts

European Journal of Organic Chemistry, Volume 29, Issue 38, 13 October 2026.
Cysteine–fluorophore conjugates were efficiently prepared through a visible‐light‐driven thiol–ene approach employing solely organic photocatalysts. The reaction proceeds under mild, metal‐free conditions. The fluorophore scope includes mono‐ and dialkene‐functionalized naphthalene, naphthalimide, and aromatic diimide derivatives.
Julieth Bellaizac‐Riascos, Pilar Ortiz‐Serna, Raúl Pérez‐Ruiz, Susana Encinas, M. Consuelo Jiménez   +4 more
wiley   +1 more source

Towards Bioorthogonal Enzymatic Uncaging Reactions

, 2016
In der vorliegenden Arbeit wird die Verwendung evolvierter Mutanten von Cytochrom-P450-Monooxygenasen als hochaktive und hochselektive Katalysatoren für die bioorthogonale Aktivierung ethermaskierter Substrate berichtet, einschließlich der erfolgreichen Entschüzung in lebenden Bakterien.
openaire   +2 more sources

Site‐Selective Tyrosine Reaction for Antibody‐Cell Conjugation and Targeted Immunotherapy

Advanced Science
Targeted immunotherapies capitalize on the exceptional binding capabilities of antibodies to stimulate a host response that effectuates long‐lived tumor destruction. One example is the conjugation of immunoglobulins (IgGs) to immune effector cells, which
Hongfei Chen, Hong‐Chai Fabio Wong, Jiaming Qiu, Biquan Li, Dingdong Yuan, Hao Kong, Yishu Bao, Yu Zhang, Zhiyi Xu, Ying‐Lung Steve Tse, Jiang Xia   +10 more
doaj   +1 more source