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Bacteria-based in vivo peptide library screening using biopanning approach
The Journal of Microbiology, 2011Traditionally, library screening has been performed to identify biologically active agents including small molecules or peptides that inhibit target proteins or molecules with therapeutic interests. Due to its chemical nature, library screening is usually performed under in vitro environments using purified proteins and molecules.
Ji-Hyeon, Choi, Sang-Hyun, Park
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Journal of Biotechnology, 2014
Biopanning of phage displayed-peptide library was performed against myoglobin, a marker for the early assessment of acute myocardial infarction (AMI), to identify peptides that selectively bind to myoglobin. Using myoglobin-conjugated magnetic beads, phages that bound to myoglobin were collected and amplified for the next round of screening. A 148-fold
Guruprasath Padmanaban +7 more
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Biopanning of phage displayed-peptide library was performed against myoglobin, a marker for the early assessment of acute myocardial infarction (AMI), to identify peptides that selectively bind to myoglobin. Using myoglobin-conjugated magnetic beads, phages that bound to myoglobin were collected and amplified for the next round of screening. A 148-fold
Guruprasath Padmanaban +7 more
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Biopanning Data Bank 2023: Updating and New Findings
Current BioinformaticsBackground: Biopanning, or phage display technology, has gained considerable research attention for discovering peptides, and antibodies, and understanding protein interactions, which are crucial for developing targeted therapeutics. The Biopanning Data Bank (BDB, http://i.uestc.edu.cn/bdb) serves as a repository for peptide biopanning results ...
Hamza B. Abagna +6 more
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Using In Vivo Biopanning for the Development of Radiation-Guided Drug Delivery Systems
2009This chapter illustrates our protocol for in vivo biopanning using T7 bacteriophage libraries for the purpose of selecting recombinant peptides for the tumor-specific delivery of radiosensitizers to radiation-inducible antigens within tumor neovasculature.
Jerry J, Jaboin +2 more
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Journal of Theoretical Biology, 1995
A mathematical model is presented for the process of selection of peptides for binding to a target. The affinity enrichment process commonly known as biopanning relies on subjecting a library of peptides on filamentous phage to a selection for binding to the target immobilized on solid support or in solution.
W, Mandecki, Y C, Chen, N, Grihalde
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A mathematical model is presented for the process of selection of peptides for binding to a target. The affinity enrichment process commonly known as biopanning relies on subjecting a library of peptides on filamentous phage to a selection for binding to the target immobilized on solid support or in solution.
W, Mandecki, Y C, Chen, N, Grihalde
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Chapter Seven Biopanning by activation tagging
2002Publisher Summary This chapter focuses on biopanning by activation tagging. Extensive gene duplication in plants and the potential of functional redundancy among homologous sequences represent a hurdle in understanding physiological and biochemical functions of a vast number of plant genes by using conventional loss-of-function mutant screen ...
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Assessing Antibody Specificity in Human Serum Using Deep Sequence-Coupled Biopanning
2019Affinity selection using phage-display technologies is a powerful tool for identifying the peptide epitopes of monoclonal antibodies. Coupling affinity selection with deep sequencing technologies allows for the broad assessment of selectant populations.
Kathryn M, Frietze +4 more
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The specific biopanning of single‐domain antibody against haptens based on a functionalized cryogel
Journal of Molecular Recognition, 2023Hongwei Zheng +2 more
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