Results 71 to 80 of about 439,388 (274)

Molecular Dynamics Simulations Reveal Canonical Conformations in Different pMHC/TCR Interactions

Cells, 2020
The major defense system against microbial pathogens in vertebrates is the adaptive immune response and represents an effective mechanism in cancer surveillance. T cells represent an essential component of this complex system.
Josephine Alba, Lorenzo Di Rienzo, Edoardo Milanetti, Oreste Acuto, Marco D’Abramo   +4 more
doaj   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Communications Biophysics [PDF]

, 1974
Contains reports on one research project.National Institutes of Health (Grant 5 PO1 GM14940 ...
Gahl, Robert A.
core   +3 more sources

Mechanotransduction mechanisms in human erythrocytes: Fundamental physiology and clinical significance

Channels
The hallmarks of mechanosensitive ion channels have been observed for half a century in various cell lines, although their mechanisms and molecular identities remained unknown until recently. Identification of the bona fide mammalian mechanosensory Piezo
Lennart Kuck, Lars Kaestner, Stéphane Egée, Virgilio L. Lew, Michael J. Simmonds   +4 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Erythrocyte Distribution by Surface Charge: Biophysical Characteristics of Heterogeneity, Diagnostic Significance and Application in Transfusionology and Biobanking

Innovative Biosystems and Bioengineering
Long-term storage of erythrocytes, a vital component of modern transfusion medicine, is accompanied by structural, metabolic, and biophysical alterations that reduce their functional activity.
Daniil Liadov, Volodymyr Berest, Tetiana Liadova, Fedir Hladkykh   +3 more
doaj   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Advancing Research on Biomaterials and Biological Materials with Scanning Electron Microscopy under Environmental and Low Vacuum Conditions

Advanced Engineering Materials, EarlyView.
Herein, environmental scanning electron microscopy (ESEM) is discussed as a powerful extension of conventional SEM for life sciences. By combining high‐resolution imaging with variable pressure and humidity, ESEM allows the analysis of untreated biological materials, supports in situ monitoring of hydration‐driven changes, and advances the functional ...
Jendrian Riedel, Lea Dierker, Antoine Eyram Kwame, Kim Nora Wagner, Jonas J. Unterholzner, Jan‐Henning Dirks, Dorothea Brüggemann   +6 more
wiley   +1 more source

Entropy and Information within Intrinsically Disordered Protein Regions

Entropy, 2019
Bioinformatics and biophysical studies of intrinsically disordered proteins and regions (IDRs) note the high entropy at individual sequence positions and in conformations sampled in solution.
Iva Pritišanac, Robert M. Vernon, Alan M. Moses, Julie D. Forman Kay   +3 more
doaj   +1 more source

Communications Biophysics [PDF]

, 1975
Contains research objectives and summary of research on thirteen research projects split into four section.National Institutes of Health (Grant 1 RO1 NS10737-01)National Institutes of Health (Grant 1 ROI NS10916-01)National Institutes of Health (Grant 5 ...
Allen, John S., Baden-Kristensen, Keld, Bahler, Lawrence G., Beguesse, Ian M., Besen, Peter D., Boland, Robert P. W., Braida, Louis D., Chow, Mark D., Colburn, H. Steven, Conrad, Chester H., Cuddy, David R., Davis, Mark F., Domnitz, Robert H., Durlach, Nathaniel I., Esquissaud, Phillipe, Freeman, Dennis M., Frishkopf, Lawrence S., Gluss, David H., Golub, Howard L., Henke, William L., Hicks, Bruce L., Houtsma, Adrian J. M., Ingard, K. Uno, Krasner, Michael A., Lim, Jae S., Lippmann, Richard P., Oman, Charles M., Peake, William T., Purks, Steven R., Rabinowitz, William M., Schultz, Martin C., Searle, Campbell L., Shepard, Neil T., Siebert, William M., Singer, Elliot, Stern, Richard M., Jr., Tole, John R., Walkowski, Yvonne M., Walters, Joseph B., Jr., Weiss, Thomas F., Wiegner, Allen W., Willett, John C.   +41 more
core