Results 71 to 80 of about 461,509 (270)

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Communications Biophysics [PDF]

, 1964
Contains a report on a research project.National Science Foundation (Grant GP-2495)National Institutes of Health (Grant MH-04737-04)National Aeronautics and Space Administration (Grant NsG ...
Barlow, J. S.
core  

Communications Biophysics [PDF]

, 1962
Contains reports on four research projects.U.S.
Blatt, H., Braun, A. G., Creasy, R. J., Cummings, F. T., Gerstein, G. L., Hall, J. L., II, Kiang, Nelson Y-S., Peake, William T.   +7 more
core   +3 more sources

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source

Single Nanoparticle Tracking Reveals Efficient Long-Distance Undercurrent Transport in Upper Fluid of Bacterial Swarms

iScience, 2019
Summary: Flagellated bacteria move collectively in a swirling pattern on agar surfaces immersed in a thin layer of viscous “swarm fluid,” but the role of this fluid in mediating the cooperation of the bacterial population is not well understood.
Jingjing Feng, Zexin Zhang, Xiaodong Wen, Jianfeng Xue, Yan He   +4 more
doaj  

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Communications Biophysics [PDF]

, 1985
Contains research objectives and reports on eight research projects split into three sections.National Institutes of Health (Grant 2 PO1 NS13126)National Institutes of Health (Grant 5 RO1 NS18682)National Institutes of Health (Grant 5 RO1 NS20322 ...
Braida, Louis D., Brown, M. Christian, Bustamante, Diane K., Colburn, H. Steven, Delgutte, Bertrand, Delhorne, Lorraine A., DeRosier, David J., Downs, Maralene M., Durlach, Nathaniel I., Eatock, Ruth Anne, Eddington, Donald K., Freeman, Dennis M., Frishkopf, Lawrence S., Gabriel, Kaigham J., Gifford, Margaret L., Girzon, Gary, Goldberg, Rina, Guinan, John J., Jr., Ito, Yoshiko, Jain, Manoj, Ketten, Darlene R., Kiang, Nelson Y-S., Kobler, James B., Koehnke, Janet A., Leotta, Daniel F., Macmillan, Neil A., McConnell, Michael V., McCue, Michael P., Oman, Charles M., Pang, Xiao-Dong, Peake, William T., Pemberton, Joseph C., Peterson, Patrick M., Posen, Miles P., Rabinowitz, William M., Reed, Charlotte M., Rose, Christopher, Rosowski, John J., Silletto, Karen, Thayer, Robert C., Thomson, Scott, Tsuk, Michael J., Uchanski, Rosalie M., Weiss, Thomas F., Zue, Victor W., Zurek, Patrick M.   +45 more
core  

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source