Results 101 to 110 of about 8,158 (274)

Endothelial histone deacetylase 1 activity impairs kidney microvascular NO signaling in rats fed a high‐salt diet

Acta Physiologica, Volume 240, Issue 9, September 2024.
Abstract Aim We aimed to test the hypothesis that a high‐salt diet (HS) impairs NO signaling in kidney microvascular endothelial cells through a histone deacetylase 1 (HDAC1)‐dependent mechanism. Methods Male Sprague Dawley rats were fed normal salt diet (NS; 0.49% NaCl) or HS (4% NaCl) for 2 weeks. NO signaling was assessed by measuring L‐NAME induced
Luke S. Dunaway, Anthony K. Cook, Cailin E. Kellum, Claudia Edell, Davide Botta, Patrick A. Molina, Randee S. Sedaka, Livius V. d'Uscio, Zvonimir S. Katusic, David M. Pollock, Edward W. Inscho, Jennifer S. Pollock   +11 more
wiley   +1 more source

Correlation between biopterin levels and intimal-media thickness in type-2 diabetic hypertensive patients

Journal of Diabetes and Metabolic Disorders, 2014
BackgroundBiopterins have a crucial role in the function of nitric oxide synthase, uncoupling of the enzyme leads to endothelial dysfunction and vascular damage, The aim of this study was to evaluate the relationship between the levels of biopterins with
A. Rubio-Guerra, H. Vargas-Robles, L. Del Valle-Mondragón, Alberto Maceda-Serrano, Saúl Huerta-Ramírez, M. B. Durán-Salgado, B. Escalante-Acosta   +6 more
semanticscholar   +1 more source

Evaluation of Serum and Urinary Levels of some Pteridine Pathway Components in Healthy Turkish Children

Pteridines, 2012
Neopterin, as a non-conjugated pteridine, is synthesized from guanosine triphosphate and its production is upregulated upon the activation of cellular immune response.
Girgin Gözde, Baydar Terken, Fuchs Dietmar, Sahin Gönül, Özmert Elif, Yurdakök Kadriye   +5 more
doaj   +1 more source

Insights from a Murine Aortic Transplantation Model [PDF]

, 2016
Transplant vasculopathy (TV) represents a major obstacle to long-term graft survival and correlates with severity of ischemia reperfusion injury (IRI). Donor administration of the nitric oxide synthases (NOS) co-factor tetrahydrobiopterin has been shown ...
Bernhard, David, Brandacher, Gerald, Cardini, Benno, Golderer, Georg, Maglione, Manuel, Messner, Barbara, Oberhuber, Rupert, Pratschke, Johann, Riede, Gregor, Steger, Christina, Watschinger, Katrin, Werner, Ernst R.   +11 more
core   +1 more source

Dispel some mist on circulating biopterins: measurement, physiological interval and pathophysiological implication [PDF]

, 2023
Shao‐Ting Wang, Haibo Wang
openalex   +1 more source

Is allostery a fuzzy concept?

FEBS Open Bio, Volume 14, Issue 7, Page 1040-1056, July 2024.
Assigning a reaction mechanism to allosteric proteins can be difficult. It is also unclear how many reaction mechanisms qualify as allosteric and the criteria used for assigning such mechanisms. Here, we define these criteria, apply them to a list of allosteric proteins, and suggest that reaction mechanism assignment should be considered preliminary ...
Veronica Morea, Francesco Angelucci, Andrea Bellelli   +2 more
wiley   +1 more source

Dopa-responsive dystonia and hyperprolactinaemia : a novel association in two sisters [PDF]

, 2007
Dopa-Responsive Dystonia (DRD) is a rare hereditary condition of childhood-onset dystonia which responds dramatically to treatment with levodopa. It was first described in 1971 as a "hereditary progressive basal ganglia disease with marked diurnal ...
Cachia, Mario J., Galea, Janabel
core  

The role of folate transport in antifolate drug action in Trypanosoma brucei [PDF]

, 2016
The aim of this study was to identify and characterize mechanisms of resistance to antifolate drugs in African trypanosomes. Genome-wide RNAi library screens were undertaken in bloodstream form Trypanosoma brucei exposed to the antifolates methotrexate ...
Ali, Alsford, Alsford, Alsford, Brun, Burkard, Carver, Chatelain, Checchi, Colasante, Dridi, Dridi, Eadsforth, Ellenberger, Fairlamb, Fairlamb, Fairlamb, Franco, Gangjee, Gangjee, Gazanion, Gibson, Glover, Goldman, Graf, Hertz-Fowler, Hirumi, Jackson, Jamonneau, Jansen, Jones, Klaus, Kündig, Langmead, Li, Massimine, Matovu, Meiser, Mpanya, Odiit, Ong, Ouameur, Panigrahi, Pelphrey, Redmond, Richard, Richard, Robays, Shanks, Sienkiewicz, Sienkiewicz, Simarro, Sirotnak, Sirotnak, Sokolova, Spinks, Synold, Tan, Ubeda, van den Hoff, Vickers, Vincent, Wahlin, Wang, Webber, Widemann, World Health Organization   +66 more
core   +2 more sources

GV‐971 attenuates the progression of neuromyelitis optica in murine models and reverses alterations in gut microbiota and associated peripheral abnormalities

CNS Neuroscience &Therapeutics, Volume 30, Issue 7, July 2024.
The NMOSD model demonstrated substantial neuroinflammation and neural injury, accompanied by imbalances in gut microbiota, peripheral inflammation, and metabolic disorders, suggesting a potentially vicious cycle that exacerbates disease pathogenesis.
Xinying Yang, Zhongheng Zhangyi, Aisong Yu, Qinming Zhou, Aihua Xia, Ji Qiu, Meixiang Cai, Xingkun Chu, Liang Li, Zhengnan Feng, Zhiyu Luo, Guangqiang Sun, Jing Zhang, Meiyu Geng, Sheng Chen, Zuoquan Xie   +15 more
wiley   +1 more source

Pterin determination in cerebrospinal fluid: state of the art

Pteridines, 2017
The analysis of pterins in the cerebrospinal fluid (CSF) is mandatory for the etiologic diagnosis of inborn errors of dopamine and serotonin metabolism.
Guibal Pierre, Lo Aurélien, Maitre Philippe, Moussa Fathi   +3 more
doaj   +1 more source